Ma Zhongze, Deng Gang, Lee David Y W
Bio-Organic and Natural Products Laboratory, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478.
Tetrahedron Lett. 2010 Sep 29;51(39):5207-5209. doi: 10.1016/j.tetlet.2010.07.144.
Salvinorin A is a naturally-occurring potent and selective kappa opioid receptor agonist, and smoking salvinorin A produces the most intense hallucinogenic effects in human. Eight neoclerodane diterpene derivatives were isolated from the smoke of salvinorin A, and their structures were identified by spectroscopic methods. The major structural changes include epimerizations, eliminations, and rearrangements.
萨尔维诺林A是一种天然存在的强效且选择性的κ阿片受体激动剂，吸食萨尔维诺林A会在人体产生最强烈的致幻效果。从萨尔维诺林A的烟雾中分离出了8种新克罗烷二萜衍生物，并通过光谱方法鉴定了它们的结构。主要的结构变化包括差向异构化、消除反应和重排反应。
