Facultad de Ciencias Médicas, Instituto de Biomedicina, Universidad Católica de Santiago de Guayaquil, Guayaquil, Ecuador.
Gynecol Endocrinol. 2011 Sep;27(9):685-91. doi: 10.3109/09513590.2010.521270. Epub 2010 Oct 12.
Prevalence of the metabolic syndrome (METS) and its components significantly increase after the menopause. Related increased cardiovascular risk may partially be explained by a pro-inflammatory state.
To assess pro-inflammatory cytokine serum levels in postmenopausal women with and without the METS.
Serum of 90 postmenopausal women who previously participated in a METS screening programme was analysed for tumour necrosis factor-alpha (TNF-α) and interleukin 6 (IL-6). Cytokine levels were compared among those with and without the syndrome, and for each of its components. Linear relationships were also assessed between cytokine levels and several continuous variables including each diagnostic METS criteria and menopausal symptoms assessed with the Menopause Specific Quality of Life tool (MENQOL).
For all studied women mean age was 55.1 ± 7.3 years with 63.3% having abdominal obesity, 15.6% hyperglycaemia, 58.9% high triglycerides, 44.4% hypertension and 25.6% high total cholesterol levels. Women with the METS (n = 45) significantly had higher body mass index values, and higher rates of abdominal obesity, hyperglycaemia, hypertriglyceridemia, hypertension and lower HDL-C levels. Cytokine levels did not differ among women with or without the METS; however, independent of METS diagnosis those with abdominal obesity displayed significantly higher IL-6 levels and those with hypertension higher levels of both cytokines. Levels of both cytokines positively correlated with age and time since menopause, IL-6 positively correlating with waist circumference values and TNF-α positively with both systolic and diastolic blood pressure levels. A significant positive correlation was also found between the number of positive METS criteria (0-5) and both cytokine levels. Cytokine levels did not correlate with vasomotor and psycho-social MENQOL scores.
Pro-inflammatory cytokine levels in this postmenopausal series positively correlated with age, time since the menopause, abdominal circumference, blood pressures levels and the number of positive METS diagnostic criteria. There is a need for more research in this regard.
代谢综合征（METS）及其组成部分的患病率在绝经后显著增加。相关的心血管风险增加可能部分解释为炎症状态。
评估患有和不患有 METS 的绝经后妇女的促炎细胞因子血清水平。
分析了之前参加 METS 筛查计划的 90 名绝经后妇女的血清肿瘤坏死因子-α（TNF-α）和白细胞介素 6（IL-6）。比较了患有和不患有该综合征的妇女以及每个综合征组成部分的细胞因子水平。还评估了细胞因子水平与几个连续变量之间的线性关系，包括每个诊断 METS 标准和绝经症状，使用绝经特异性生活质量工具（MENQOL）评估。
对于所有研究妇女，平均年龄为 55.1 ± 7.3 岁，63.3%有腹部肥胖，15.6%有高血糖，58.9%有高甘油三酯，44.4%有高血压，25.6%有高总胆固醇水平。患有 METS（n = 45）的妇女体重指数值显著较高，且腹部肥胖、高血糖、高甘油三酯、高血压和低高密度脂蛋白胆固醇水平的发生率较高。患有或不患有 METS 的妇女之间的细胞因子水平没有差异；然而，独立于 METS 诊断，腹部肥胖的妇女 IL-6 水平显著较高，高血压的妇女两种细胞因子水平均较高。两种细胞因子的水平与年龄和绝经后时间呈正相关，IL-6 与腰围值呈正相关，TNF-α与收缩压和舒张压水平均呈正相关。METS 阳性标准（0-5 个）的数量与两种细胞因子水平之间也存在显著正相关。细胞因子水平与血管舒缩和心理社会 MENQOL 评分无相关性。
在这个绝经后系列中，促炎细胞因子水平与年龄、绝经后时间、腹部周长、血压水平和阳性 METS 诊断标准的数量呈正相关。这方面需要进一步研究。
