下咽鳞癌中 Oct4 和 Sox2 表达的预后意义。
Prognostic significance of Oct4 and Sox2 expression in hypopharyngeal squamous cell carcinoma.
机构信息
State Key Laboratory of Oncology in South China, Cancer Center of Sun Yat-Sen University, Guangzhou 510060, China.
出版信息
J Transl Med. 2010 Oct 12;8:94. doi: 10.1186/1479-5876-8-94.
BACKGROUND
Oct4 and Sox2 are two major transcription factors related to the stem cell self-renewal and differentiation. The aim of this study was to examine the association between Oct4 and Sox2 expression levels with both the clinicopathological characteristics and prognoses of patients with hypopharyngeal squamous cell carcinoma.
METHOD
Tumor tissue samples from 85 patients with hypopharyngeal squamous cell carcinoma were collected, and the clinical follow-up data of these patients were recorded, and expression status of Oct4 and Sox2 were examined in these tissue samples by immunohistochemistry (IHC).
RESULTS
Oct4 expression was found to be an independent predictive factor for overall survival (p = 0.004) in patients with hypopharyngeal squamous cell carcinoma and was independently related to loco-regional control (p = 0.001). Although Sox2 expression status showed no significant association with overall survival (p = 0.166), disease-free survival (p = 0.680) or loco-regional control (p = 0.383), when using a subgroup analysis, the subgroup with both high Oct4 and Sox2 expression had the best prognosis (p = 0.000). Sox2 expression could be a potential prognostic predictor for patients with hypopharyngeal squamous cell carcinoma. Simultaneous analyses of Oct4 and Sox2 expression could be more effective in evaluating the prognoses of patients with hypopharyngeal squamous cell carcinoma.
CONCLUSION
Oct4 expression is an independent predictive factor for patients with hypopharyngeal squamous cell carcinoma, suggesting that Oct4 expression may be a useful indicator for predicting the prognosis of hypopharyngeal squamous cell carcinoma.
背景
Oct4 和 Sox2 是与干细胞自我更新和分化相关的两个主要转录因子。本研究旨在探讨 Oct4 和 Sox2 表达水平与下咽鳞状细胞癌患者的临床病理特征和预后之间的关系。
方法
收集 85 例下咽鳞状细胞癌患者的肿瘤组织样本，记录这些患者的临床随访资料，并通过免疫组织化学（IHC）检测这些组织样本中 Oct4 和 Sox2 的表达状态。
结果
Oct4 表达被发现是下咽鳞状细胞癌患者总生存的独立预测因子（p = 0.004），并且与局部区域控制独立相关（p = 0.001）。虽然 Sox2 表达状态与总生存（p = 0.166）、无病生存（p = 0.680）或局部区域控制（p = 0.383）均无显著相关性，但在亚组分析中，同时具有高 Oct4 和 Sox2 表达的亚组具有最佳的预后（p = 0.000）。Sox2 表达可能是下咽鳞状细胞癌患者的潜在预后预测因子。同时分析 Oct4 和 Sox2 表达可能更有效地评估下咽鳞状细胞癌患者的预后。
结论
Oct4 表达是下咽鳞状细胞癌患者的独立预测因子，表明 Oct4 表达可能是预测下咽鳞状细胞癌预后的有用指标。
Zotero 插件