Department of Neurology, University of Florence, Florence, Italy.
Neurol Sci. 2010 Aug;31(4):467-70. doi: 10.1007/s10072-010-0281-x. Epub 2010 May 8.
In adult-onset multiple sclerosis (MS) cases, major depression, fatigue and psychological distress are common, whereas there is little information on these issues in children with the disease. The aim of this study was to assess psychosocial disorders in an Italian cohort of children and adolescent with MS. We evaluated 56 patients through self-assessment scales of depression (Children Depression Inventory) and fatigue (Fatigue Severity Scale), a psychiatric interview [Kiddie-SADS-Present and Lifetime Version (K-SADS-PL)] and an interview on school and everyday activities. Significant fatigue was found in 11 patients (20%). Twelve of the 39 patients who underwent the K-SADS-PL received a formal diagnosis of an affective disorder. Moreover, MS affected school activities in 28% of cases, daily living activities in 41% and social relationships in 28%. Our study confirms the critical role of psychosocial difficulties in children and adolescents with MS and provides a few cues to clinical management.
在成人发病的多发性硬化症 (MS) 病例中，重度抑郁、疲劳和心理困扰很常见，但针对儿童患者，这方面的信息却很少。本研究旨在评估意大利多发性硬化症儿童和青少年患者的心理障碍。我们通过抑郁自评量表（儿童抑郁量表）和疲劳自评量表（疲劳严重程度量表）、精神病访谈[儿童定式访谈及半定式访谈（Kiddie-SADS-Present and Lifetime Version，K-SADS-PL）]以及关于学校和日常活动的访谈，对 56 名患者进行了评估。11 名患者（20%）存在明显疲劳。在接受 K-SADS-PL 访谈的 39 名患者中，有 12 名被正式诊断为情感障碍。此外，MS 影响了 28%的病例的学校活动，41%的病例的日常生活活动和 28%的病例的社会关系。本研究证实了心理社会困难在多发性硬化症儿童和青少年中的关键作用，并为临床管理提供了一些线索。
