Department of Clinical Sciences and Bioimaging, Infrared Imaging Laboratory, Institute of Advanced Biomedical Technologies, University G d'Annunzio Chieti-Pescara, Via dei Vestini 31, I-66013 Chieti Scalo, CH, Italy.
Arch Gerontol Geriatr. 2011 Sep-Oct;53(2):135-40. doi: 10.1016/j.archger.2010.09.011. Epub 2010 Oct 10.
LJM is frequently observed in young subjects with insulin-dependent diabetes mellitus (IDDM). Aim of this study was to evaluate whether non-insulin-dependent diabetes mellitus (NIDDM) increases the risk of LJM in elderly subjects. Thirty patients (15 males, 15 females, mean age 73.93 ± 12.72 years) with NIDDM in good glycemic control were compared with thirty non-diabetic elderly, well matched for sex and age (15 males, 15 females, mean age 74.3 ± 4.24 years), and with ten young normal subjects (5 males, 5 females, mean age 26.3 ± 1.56 years). In these subjects, the range of motion (ROM) of ankle, knee, hip, elbow and shoulder were measured with a double-armed goniometer. Moreover, abnormalities of supraspinatus, patellar and Achilles tendons were evaluated with a standardized ultrasound (US) procedure. A significant reduction in the mobility of all joints was found in elderly subjects, compared to younger ones, with exception for the knee and elbow flexion. Elderly patients with diabetes, compared with their age-matched counterpart, showed LJM for ankle dorso- and plantar flexion, hip flexion and adduction, shoulder abduction and flexion. Moreover, tendons sonographic abnormalities were more frequently observed in diabetics. Our data confirm that diabetes worsens the LJM in the elderly, increasing the cross-linking of collagen by the non-enzymatic advanced glycation end products formation.
LJM 在年轻的胰岛素依赖型糖尿病（IDDM）患者中经常观察到。本研究旨在评估非胰岛素依赖型糖尿病（NIDDM）是否会增加老年患者 LJM 的风险。将 30 例血糖控制良好的 NIDDM 患者（15 名男性，15 名女性，平均年龄 73.93 ± 12.72 岁）与 30 名年龄和性别相匹配的非糖尿病老年患者（15 名男性，15 名女性，平均年龄 74.3 ± 4.24 岁）和 10 名年轻的正常受试者（5 名男性，5 名女性，平均年龄 26.3 ± 1.56 岁）进行比较。在这些受试者中，使用双臂量角器测量踝关节、膝关节、髋关节、肘关节和肩关节的活动度（ROM）。此外，使用标准化超声（US）程序评估冈上肌腱、髌腱和跟腱的异常。与年轻受试者相比，老年受试者的所有关节活动度均明显降低，除了膝关节和肘关节的屈曲。与年龄匹配的对照组相比，糖尿病老年患者的踝关节背屈和跖屈、髋关节屈曲和内收、肩关节外展和屈曲的 LJM 更为明显。此外，糖尿病患者的肌腱超声异常更为常见。我们的数据证实，糖尿病会加重老年人的 LJM，增加非酶促糖基化终产物形成导致的胶原蛋白交联。
