能量景观作为整合 G 蛋白偶联受体结构、动力学和功能的工具。
Energy landscapes as a tool to integrate GPCR structure, dynamics, and function.
机构信息
Unitat de Bioestadística, Facultat de Medicina, Universitat Autònoma de Barcelona, Catalunya, Spain.
出版信息
Physiology (Bethesda). 2010 Oct;25(5):293-303. doi: 10.1152/physiol.00002.2010.
Abstract
G protein-coupled receptors (GPCRs) are versatile signaling molecules that mediate the majority of physiological responses to hormones and neurotransmitters. Recent high-resolution structural insights into GPCR structure and dynamics are beginning to shed light on the molecular basis of this versatility. We use energy landscapes to conceptualize the link between structure and function.
摘要
G 蛋白偶联受体（GPCRs）是多功能的信号分子，介导了大多数激素和神经递质的生理反应。最近对 GPCR 结构和动力学的高分辨率结构见解开始揭示这种多功能性的分子基础。我们使用能量景观来概念化结构和功能之间的联系。
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