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蛋白质的结构分类与结构基因组学：对蛋白质折叠和进化的新见解

Structural classification of proteins and structural genomics: new insights into protein folding and evolution.

作者信息

Andreeva Antonina, Murzin Alexey G

机构信息

MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, England.

出版信息

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Oct 1;66(Pt 10):1190-7. doi: 10.1107/S1744309110007177. Epub 2010 Jul 6.

DOI:10.1107/S1744309110007177
PMID:20944210
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2954204/
Abstract

During the past decade, the Protein Structure Initiative (PSI) centres have become major contributors of new families, superfamilies and folds to the Structural Classification of Proteins (SCOP) database. The PSI results have increased the diversity of protein structural space and accelerated our understanding of it. This review article surveys a selection of protein structures determined by the Joint Center for Structural Genomics (JCSG). It presents previously undescribed β-sheet architectures such as the double barrel and spiral β-roll and discusses new examples of unusual topologies and peculiar structural features observed in proteins characterized by the JCSG and other Structural Genomics centres.

摘要

在过去十年中，蛋白质结构计划（PSI）中心已成为蛋白质结构分类（SCOP）数据库新家族、超家族和折叠类型的主要贡献者。PSI的成果增加了蛋白质结构空间的多样性，并加速了我们对其的理解。这篇综述文章调查了由结构基因组学联合中心（JCSG）确定的一系列蛋白质结构。它展示了以前未描述过的β折叠结构，如双桶状和螺旋β卷，并讨论了在JCSG和其他结构基因组学中心鉴定的蛋白质中观察到的异常拓扑结构和特殊结构特征的新例子。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20fa/2954204/bd12434ebd49/f-66-01190-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20fa/2954204/9f1a659f7101/f-66-01190-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20fa/2954204/f5670a9c7b44/f-66-01190-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20fa/2954204/bde565c650e4/f-66-01190-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20fa/2954204/cd82c080b3a3/f-66-01190-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20fa/2954204/892ce33ecd06/f-66-01190-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20fa/2954204/ac3f58626bbc/f-66-01190-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20fa/2954204/bd12434ebd49/f-66-01190-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20fa/2954204/9f1a659f7101/f-66-01190-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20fa/2954204/f5670a9c7b44/f-66-01190-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20fa/2954204/bde565c650e4/f-66-01190-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20fa/2954204/cd82c080b3a3/f-66-01190-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20fa/2954204/892ce33ecd06/f-66-01190-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20fa/2954204/ac3f58626bbc/f-66-01190-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20fa/2954204/bd12434ebd49/f-66-01190-fig7.jpg

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