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Too much inhibition leads to excitation in absence epilepsy.

作者信息

Wong Michael

出版信息

Epilepsy Curr. 2010 Sep;10(5):131-2. doi: 10.1111/j.1535-7511.2010.01379.x.

DOI:10.1111/j.1535-7511.2010.01379.x
PMID:20944826
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2951695/
Abstract
摘要

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本文引用的文献

1
Mutations affecting GABAergic signaling in seizures and epilepsy.影响癫痫发作和癫痫中 GABA 能信号的突变。
Pflugers Arch. 2010 Jul;460(2):505-23. doi: 10.1007/s00424-010-0816-2. Epub 2010 Mar 30.
2
Enhanced tonic GABAA inhibition in typical absence epilepsy.典型失神癫痫中强直性GABAA抑制增强。
Nat Med. 2009 Dec;15(12):1392-8. doi: 10.1038/nm.2058. Epub 2009 Nov 22.
3
Neurons that fire together also conspire together: is normal sleep circuitry hijacked to generate epilepsy?一起放电的神经元也会协同作用：正常睡眠回路是否被劫持以引发癫痫？
Neuron. 2009 Jun 11;62(5):612-32. doi: 10.1016/j.neuron.2009.05.015.
4
Enhanced tonic GABA current in normotopic and hilar ectopic dentate granule cells after pilocarpine-induced status epilepticus.毛果芸香碱诱导癫痫持续状态后，正常位置和海马门异位齿状颗粒细胞中强直性GABA电流增强。
J Neurophysiol. 2009 Aug;102(2):670-81. doi: 10.1152/jn.00147.2009. Epub 2009 May 27.
5
Seizures and enhanced cortical GABAergic inhibition in two mouse models of human autosomal dominant nocturnal frontal lobe epilepsy.人类常染色体显性遗传性夜间额叶癫痫的两种小鼠模型中的癫痫发作及增强的皮质γ-氨基丁酸能抑制作用
Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19152-7. doi: 10.1073/pnas.0608215103. Epub 2006 Dec 4.
6
Multiple and plastic receptors mediate tonic GABAA receptor currents in the hippocampus.多种可塑性受体介导海马体中的紧张性GABAA受体电流。
J Neurosci. 2005 Oct 26;25(43):10016-24. doi: 10.1523/JNEUROSCI.2520-05.2005.
7
Trafficking of GABA(A) receptors, loss of inhibition, and a mechanism for pharmacoresistance in status epilepticus.γ-氨基丁酸A型（GABA(A)）受体的转运、抑制作用丧失与癫痫持续状态下耐药性的机制
J Neurosci. 2005 Aug 24;25(34):7724-33. doi: 10.1523/JNEUROSCI.4944-04.2005.
8
GABAergic mechanisms in epilepsy.癫痫中的γ-氨基丁酸能机制。
Epilepsia. 2001;42 Suppl 3:8-12. doi: 10.1046/j.1528-1157.2001.042suppl.3008.x.
9
GABA uptake and heterotransport are impaired in the dentate gyrus of epileptic rats and humans with temporal lobe sclerosis.在患有颞叶硬化症的癫痫大鼠和人类的齿状回中，γ-氨基丁酸（GABA）摄取和异质转运受损。
J Neurophysiol. 2001 Apr;85(4):1533-42. doi: 10.1152/jn.2001.85.4.1533.
10
Utility of the lethargic (lh/lh) mouse model of absence seizures in predicting the effects of lamotrigine, vigabatrin, tiagabine, gabapentin, and topiramate against human absence seizures.失神发作的昏睡（lh/lh）小鼠模型在预测拉莫三嗪、氨己烯酸、噻加宾、加巴喷丁和托吡酯对人类失神发作疗效方面的效用。
Epilepsia. 1997 Apr;38(4):408-14. doi: 10.1111/j.1528-1157.1997.tb01729.x.