Mechanical and Materials Engineering, Florida International University, Miami, Florida 33174, USA.
J Biomed Mater Res A. 2011 Jan;96(1):1-12. doi: 10.1002/jbm.a.32952. Epub 2010 Oct 13.
This work evaluates the effect of carbon nanotube (CNT) addition to plasma-sprayed hydroxyapatite (HA) coating on its tribological behavior, biocompatibility of the coating, and cytotoxicity of CNT-containing wear debris. Biological response of the CNT-containing wear debris is critical for osteoblasts, the bone-forming cells, and macrophages, the cells that clear up wear debris from blood stream. The addition of 4 wt % CNTs to HA coating reduces the volume of wear debris generation by 80% because of the improved elastic modulus and fracture toughness. CNT reinforcement has a pronounced effect on the particle size in the wear debris and subsequent biological response. There was a slight increase in the numbers and viability of osteoblasts grown on HA-CNT compared with HA alone. The cytotoxic effect of HA and HA-CNT debris to macrophages and osteoblasts was similar, demonstrating that loose CNT does not pose a problem to these cells.
这项工作评估了向等离子喷涂羟基磷灰石（HA）涂层中添加碳纳米管（CNT）对其摩擦学行为、涂层生物相容性和含 CNT 磨屑细胞毒性的影响。含 CNT 磨屑的生物反应对成骨细胞（骨形成细胞）和巨噬细胞（从血液中清除磨屑的细胞）至关重要。由于弹性模量和断裂韧性的提高，向 HA 涂层中添加 4wt%的 CNT 将磨屑生成量减少了 80%。CNT 增强对磨屑中的颗粒尺寸和随后的生物反应有显著影响。与单独的 HA 相比，在 HA-CNT 上生长的成骨细胞数量和活力略有增加。HA 和 HA-CNT 颗粒对巨噬细胞和成骨细胞的细胞毒性作用相似，表明松散的 CNT 不会对这些细胞造成问题。
