First Internal Clinic, Medical Faculty, P. J. Safarik University, Kosice, Slovak Republic.
Physiol Res. 2011;60(1):15-25. doi: 10.33549/physiolres.931903. Epub 2010 Oct 15.
Serotonin (5-hydroxytryptamine) is an ubiquitary monoamine acting as one of the neurotransmitters at synapses of nerve cells. Serotonin acts through several receptor types and subtypes. The profusion of 5-HT receptors should eventually allow a better understanding of the different and complex processes in which serotonin is involved. Its role is expected in the etiology of several diseases, including depression, schizophrenia, anxiety and panic disorders, migraine, hypertension, pulmonary hypertension, eating disorders, vomiting and irritable bowel syndromes. In the past 20 years, seven distinct families of 5-HT receptors have been identified and various subpopulations have been described for several of them. Increasing number of 5-HT receptors has made it difficult to unravel the role of 5-HT receptor subpopulations due to the lack of suitable selective agents. The present review describes the different populations and nomenclature of recently discovered 5-HT receptors and their pharmacological relevance.
血清素（5-羟色胺）是一种普遍存在的单胺类物质，作为神经细胞突触处的神经递质之一。血清素通过几种受体类型和亚型发挥作用。5-HT 受体的丰富多样性最终应该有助于更好地理解涉及血清素的不同和复杂的过程。它的作用预计涉及几种疾病的病因，包括抑郁症、精神分裂症、焦虑症和恐慌症、偏头痛、高血压、肺动脉高压、饮食失调、呕吐和肠易激综合征。在过去的 20 年中，已经确定了七种不同的 5-HT 受体家族，并且对其中的几种受体描述了各种亚群。由于缺乏合适的选择性试剂，越来越多的 5-HT 受体使得难以阐明 5-HT 受体亚群的作用。本综述描述了最近发现的 5-HT 受体的不同群体和命名法及其药理学相关性。
