Department of Cell and Developmental Biology, Pasteur Institute-Cenci Bolognetti Foundation, Sapienza University of Rome, Rome, Italy.
FEMS Yeast Res. 2010 Dec;10(8):1006-22. doi: 10.1111/j.1567-1364.2010.00685.x. Epub 2010 Oct 14.
Nowadays, mitochondrial diseases are recognized and studied with much attention and they cannot be considered anymore as 'rare diseases'. Yeast has been an instrumental organism to understand the genetic and molecular aspects of the many roles of mitochondria within the cells. Thanks to the general conservation of mitochondrial genes and pathways between human and yeast, it can also be used to model some diseases. In this review, we focus on the most recent topics, exemplifying those for which yeast models have been especially valuable.
如今，线粒体疾病受到了广泛关注和深入研究，它们不再被视为“罕见病”。酵母一直是研究线粒体在细胞中多种作用的遗传和分子方面的重要工具。由于人类和酵母中线粒体基因和途径的普遍保守性，酵母也可用于模拟某些疾病。在这篇综述中，我们重点介绍了一些最新的研究主题，并举例说明了酵母模型特别有价值的那些主题。
