Cancer Epidemiology Branch, Division of Cancer Epidemiology and Management, Research Institute, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do 410-769, Republic of Korea.
Cancer Epidemiol. 2010 Dec;34(6):713-6. doi: 10.1016/j.canep.2010.09.003. Epub 2010 Oct 13.
Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are important risk factors for hepatocellular carcinoma (HCC). Yet, there have been few studies on adherence to screening recommendations for groups at high risk for HCC. We assessed whether demographic factors or medical conditions affected screening participation among HBV/HCV carriers.
The study population consisted of 15565 men and women who visited the National Cancer Center, Korea between August 2002 and July 2009. A self-administered questionnaire was used to collect information on demographic characteristics, medical history, including chronic HBV and HCV infection, and health check-up history. HBV surface antigen and HCV antibody levels were measured in serum.
Among 781 HBV carriers, 596 (76.3%) were aware of their infection and 451 (57.8%) had ever been tested by ultrasonography. Among HCV carriers, 49 of 127 (36.6%) were aware of their infection and 61 (48.0%) had ever been tested by ultrasonography. Among HBV carriers, male sex (OR, 1.68; 95% CI, 1.22-2.31), family history of liver disease (OR, 2.04; 95% CI, 1.43-2.90), medical history of hyperlipidemia (OR, 2.70; 95% CI, 1.36-5.33), and awareness of infection status (OR, 4.30; 95% CI, 2.99-6.17) were associated with being tested. Among HCV carriers, awareness of infection (OR, 3.77; 95% CI, 1.72-8.26) was significantly associated with being tested by ultrasonography.
Male sex, family history of liver disease, medical history of hyperlipidemia, and awareness of high risk status were associated with being tested by ultrasonography.
慢性乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）感染是肝细胞癌（HCC）的重要危险因素。然而，对于高危 HCC 人群的筛查建议的依从性研究甚少。我们评估了人口统计学因素或医疗状况是否会影响 HBV/HCV 携带者的筛查参与度。
研究人群由 2002 年 8 月至 2009 年 7 月期间访问韩国国家癌症中心的 15565 名男性和女性组成。使用自填式问卷收集人口统计学特征、医疗史（包括慢性 HBV 和 HCV 感染）和健康检查史信息。血清中检测 HBV 表面抗原和 HCV 抗体水平。
在 781 名 HBV 携带者中，596 名（76.3%）知晓自己的感染情况，451 名（57.8%）曾接受过超声检查。在 127 名 HCV 携带者中，49 名（36.6%）知晓自己的感染情况，61 名（48.0%）曾接受过超声检查。在 HBV 携带者中，男性（OR，1.68；95%CI，1.22-2.31）、家族性肝病史（OR，2.04；95%CI，1.43-2.90）、高脂血症史（OR，2.70；95%CI，1.36-5.33）和感染状况知晓（OR，4.30；95%CI，2.99-6.17）与接受检查相关。在 HCV 携带者中，感染状况知晓（OR，3.77；95%CI，1.72-8.26）与接受超声检查显著相关。
男性、家族性肝病史、高脂血症史和高危状态知晓与超声检查有关。
