Department of Otolaryngology, Catholic University, Rome, Italy.
Acta Otorhinolaryngol Ital. 2010 Jun;30(3):125-30.
The salivary proteome is a complex protein mixture resulting from the activity of salivary glands with the contribution of other components that form the oral environment such as oral tissues and micro-organisms. For diagnosis purposes, saliva collection has the great advantage of being an easy and non-invasive technique. Human saliva proteomics have proven to be a novel approach in the search for protein biomarkers for detection of different local and systemic diseases. Currently, more than 1400 salivary proteins have been identified. In the last few years, our research group has extensively studied the salivary proteomics in order to analyse the salivary composition, investigating the major families of proteins present in human and mammalian saliva, the post-translational modifications, the different contributions of glands, the physiological and pathological modifications of saliva. The aim of this report is to present our personal experience in salivary proteomics. In conclusion, salivary proteome analysis represents an important field both for diagnosis and monitoring of various diseases and could be considered a novel approach to prevention of various pathological conditions.
唾液蛋白质组是唾液腺活动产生的复杂蛋白质混合物，其他构成口腔环境的成分，如口腔组织和微生物，也对其有贡献。就诊断目的而言，唾液采集具有作为一种简便、非侵入性技术的巨大优势。唾液蛋白质组学已被证明是一种寻找用于检测不同局部和全身疾病的蛋白质生物标志物的新方法。目前，已经鉴定出超过 1400 种唾液蛋白质。在过去的几年中，我们的研究小组广泛研究了唾液蛋白质组学，以分析唾液成分，研究存在于人类和哺乳动物唾液中的主要蛋白质家族、翻译后修饰、不同腺体的贡献、唾液的生理和病理变化。本报告的目的是介绍我们在唾液蛋白质组学方面的个人经验。总之，唾液蛋白质组分析在各种疾病的诊断和监测方面具有重要意义，可被视为预防各种病理状况的新方法。
