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BMC Bioinformatics. 2010 Jan 20;11:39. doi: 10.1186/1471-2105-11-39.
2
Surfome analysis as a fast track to vaccine discovery: identification of a novel protective antigen for Group B Streptococcus hypervirulent strain COH1.表面组分析作为疫苗研发的快速通道：鉴定B族链球菌高毒力菌株COH1的一种新型保护性抗原。
Mol Cell Proteomics. 2009 Jul;8(7):1728-37. doi: 10.1074/mcp.M800486-MCP200. Epub 2009 Apr 28.
3
Proteomics characterization of outer membrane vesicles from the extraintestinal pathogenic Escherichia coli DeltatolR IHE3034 mutant.肠外致病性大肠杆菌DeltatolR IHE3034突变体的外膜囊泡的蛋白质组学特征分析
Mol Cell Proteomics. 2008 Mar;7(3):473-85. doi: 10.1074/mcp.M700295-MCP200. Epub 2007 Nov 2.
4
A surface-focused biotinylation procedure identifies the Yersinia pestis catalase KatY as a membrane-associated but non-surface-located protein.一种表面聚焦的生物素化方法鉴定出鼠疫耶尔森菌过氧化氢酶KatY是一种与膜相关但非位于表面的蛋白质。
Appl Environ Microbiol. 2007 Sep;73(18):5750-9. doi: 10.1128/AEM.02968-06. Epub 2007 Jul 20.
5
Surface-exposed proteins of Ehrlichia chaffeensis.恰菲埃立克体的表面暴露蛋白。
Infect Immun. 2007 Aug;75(8):3833-41. doi: 10.1128/IAI.00188-07. Epub 2007 May 21.
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The identification of surface proteins of Burkholderia pseudomallei.
Vaccine. 2007 Mar 30;25(14):2664-72. doi: 10.1016/j.vaccine.2006.12.006. Epub 2006 Dec 26.
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8
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9
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Mol Microbiol. 2006 Aug;61(4):839-46. doi: 10.1111/j.1365-2958.2006.05272.x.
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A universal vaccine for serogroup B meningococcus.一种针对B群脑膜炎球菌的通用疫苗。
Proc Natl Acad Sci U S A. 2006 Jul 18;103(29):10834-9. doi: 10.1073/pnas.0603940103. Epub 2006 Jul 6.

细菌表面蛋白与疫苗。

Bacterial surface proteins and vaccines.

作者信息

Grandi Guido

机构信息

Novartis Vaccines and Diagnostics Via Fiorentina 1, 53100, Siena Italy.

出版信息

F1000 Biol Rep. 2010 May 11;2:36. doi: 10.3410/B2-36.

DOI:10.3410/B2-36
PMID:20948798
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2950030/
Abstract

Surface-associated proteins play a key role in bacterial physiology and pathogenesis and are the major targets for vaccine development. Recent advances in defining the proteins associated with, and protruding out of, bacterial cells to a high level of accuracy are substantially contributing to accelerating the process of vaccine target identification and development.

摘要

表面相关蛋白在细菌生理学和发病机制中起关键作用，是疫苗开发的主要靶点。在高精度鉴定与细菌细胞相关并突出于细菌细胞外的蛋白方面取得的最新进展，正极大地推动疫苗靶点识别和开发进程。