Edwards Keith H, Gibson G Anthony
LensAR Inc, Winter Park, Florida 32789, USA.
Clin Exp Optom. 2010 Nov;93(6):390-9. doi: 10.1111/j.1444-0938.2010.00538.x. Epub 2010 Oct 18.
There is increasing interest in the effects of reactive oxygen species ('free radicals') in ageing, both in the body overall and specifically in the eye. Cataract and age-related macular degeneration (AMD) are two major causes of blindness, with cataract accounting for 48 per cent of world blindness and AMD accounting for 8.7 per cent. Both cataract and AMD affect an older population (over 50 years of age) and while cataract is largely treatable provided resources are available, AMD is a common cause of untreatable, progressive visual loss. There is evidence that AMD is linked to exposure to short wavelength electromagnetic radiation, which includes ultraviolet, blue and violet wavelengths. The ageing crystalline lens provides some protection to the posterior pole because, as it yellows with age, its spectral absorption increasingly blocks the shorter wavelengths of light. Ultraviolet blocking intraocular lenses (IOLs) have been the standard of care for many years but a more recent trend is to include blue-blocking filters based on theoretical benefits. As these filters absorb part of the visible spectrum, they may affect visual function. This review looks at the risks and the benefits of filtering out short wavelength light in pseudophakic patients.
活性氧(“自由基”)对整体身体尤其是眼睛衰老的影响,正受到越来越多的关注。白内障和年龄相关性黄斑变性(AMD)是导致失明的两大主要原因,白内障占全球失明病例的48%,AMD占8.7%。白内障和AMD都影响老年人群(50岁以上),虽然白内障在有资源的情况下基本可治疗,但AMD是不可治疗的渐进性视力丧失的常见原因。有证据表明,AMD与暴露于短波长电磁辐射有关,其中包括紫外线、蓝光和紫光波长。随着年龄增长而变黄的晶状体可为后极提供一定保护,因为其光谱吸收会越来越多地阻挡较短波长的光。紫外线阻断人工晶状体(IOL)多年来一直是标准治疗手段,但最近的趋势是基于理论益处加入蓝光阻断滤光片。由于这些滤光片会吸收部分可见光谱,它们可能会影响视觉功能。这篇综述探讨了在人工晶状体植入患者中滤除短波长光的风险和益处。