Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, China.
Am J Reprod Immunol. 2011 May;65(5):521-5. doi: 10.1111/j.1600-0897.2010.00924.x. Epub 2010 Oct 18.
An association of polymorphism -1154G/A (rs1570360) in vascular endothelial growth factor (VEGF) gene with idiopathic recurrent spontaneous abortion (RSA) has been found in Caucasians. The aim of this study was to examine the association of VEGF -1154 with RSA in a well-defined group of Chinese Han patients.
The VEGF -1154G/A genotype was detected by real-time PCR with TaqMan probes. The products were also subjected to gene sequence analysis to validate the PCR results.
The allele frequencies of VEGF -1154G/A showed no significant difference between RSA patients and the normal controls (P = 0.183). The frequencies of VEGF -1154G/A genotypes were not significantly different between RSA patients and the normal controls (P = 0.228).
Our study revealed that VEGF -1154G/A polymorphism was not associated with the susceptibility to RSA in Chinese Han women.
在白种人中发现血管内皮生长因子（VEGF）基因的多态性-1154G/A（rs1570360）与特发性复发性自然流产（RSA）有关。本研究的目的是在一个明确的中国汉族患者群体中研究 VEGF-1154 与 RSA 的相关性。
通过实时 PCR 与 TaqMan 探针检测 VEGF-1154G/A 基因型。还对产物进行基因序列分析以验证 PCR 结果。
VEGF-1154G/A 等位基因频率在 RSA 患者和正常对照组之间无显著差异（P=0.183）。VEGF-1154G/A 基因型频率在 RSA 患者和正常对照组之间无显著差异（P=0.228）。
本研究表明 VEGF-1154G/A 多态性与中国汉族妇女 RSA 的易感性无关。
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