Department of Anesthesiology, Maastricht University Medical Center, Maastricht, The Netherlands.
Prog Neurobiol. 2010 Nov;92(3):245-76. doi: 10.1016/j.pneurobio.2010.10.002. Epub 2010 Oct 13.
Peripheral nerve injuries that induce gaps larger than 1-2 cm require bridging strategies for repair. Autologous nerve grafts are still the gold standard for such interventions, although alternative treatments, as well as treatments to improve the therapeutic efficacy of autologous nerve grafting are generating increasing interest. Investigations are still mostly experimental, although some clinical studies have been undertaken. In this review, we aim to describe the developments in bridging technology which aim to replace the autograft. A multi-disciplinary approach is of utmost importance to develop and optimise treatments of the most challenging peripheral nerve injuries.
对于导致间隙大于 1-2 厘米的周围神经损伤，需要进行桥接修复策略。自体神经移植仍然是此类干预的金标准，尽管替代治疗以及提高自体神经移植治疗效果的治疗方法越来越受到关注。尽管已经进行了一些临床研究，但这些研究仍主要是实验性的。在这篇综述中，我们旨在描述旨在替代自体移植物的桥接技术的发展。多学科方法对于开发和优化最具挑战性的周围神经损伤的治疗至关重要。
