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茵陈蒿对 1 型糖尿病大鼠的降血糖、降血脂及体内抗氧化作用的研究：潜在生物标志物的鉴定。

Investigation of Antidiabetic, Antihyperlipidemic, and In Vivo Antioxidant Properties of Sphaeranthus indicus Linn. in Type 1 Diabetic Rats: An Identification of Possible Biomarkers.

机构信息

Department of Pharmacology, KMCH College of Pharmacy, Tamil Nadu, Coimbatore 641 048, India.

出版信息

Evid Based Complement Alternat Med. 2011;2011. doi: 10.1155/2011/571721. Epub 2010 Sep 26.

DOI:10.1155/2011/571721
PMID:20953435
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2952313/
Abstract

The present investigation was aimed to study the antidiabetic, antihyperlipidemic, and in vivo antioxidant properties of the root of Sphaeranthus indicus Linn. in streptozotocin- (STZ-) induced type 1 diabetic rats. Administration of ethanolic extract of Sphaeranthus indicus root (EESIR) 100 and 200 mg/kg to the STZ-induced diabetic rats showed significant (P < .01) reduction in blood glucose and increase in body weight compared to diabetic control rats. Both the doses of EESIR-treated diabetic rats showed significant (P < .01) alteration in elevated lipid profile levels than diabetic control rats. The EESIR treatment in diabetic rats produced significant increase in superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and decrease in thiobarbituric acid reactive substances (TBARS) levels than diabetic control rats. Administration of EESIR 200 mg/kg produced significant (P < .01) higher antioxidant activity than EESIR 100 mg/kg. The high performance liquid chromatography (HPLC) analysis of EESIR revealed the presence of biomarkers gallic acid and quercetin. In conclusion, EESIR possess antidiabetic, antihyperlipidemic, and in vivo antioxidant activity in type 1 diabetic rats. Its antioxidant and lipid lowering effect will help to prevent diabetic complications, and these actions are possibly due to presence of above biomarkers.

摘要

本研究旨在探讨醉茄根（Sphaeranthus indicus Linn.）的抗糖尿病、抗高血脂和体内抗氧化特性。给予链脲佐菌素（STZ）诱导的 1 型糖尿病大鼠醉茄根的乙醇提取物（EESIR）100 和 200mg/kg，与糖尿病对照组大鼠相比，血糖显著降低（P<0.01），体重增加。与糖尿病对照组大鼠相比，两种剂量的 EESIR 治疗的糖尿病大鼠的升高脂质谱水平均发生显著变化（P<0.01）。EESIR 治疗糖尿病大鼠可显著增加超氧化物歧化酶（SOD）、过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GPx）的水平，降低丙二醛（TBARS）的水平（P<0.01）。与 EESIR 100mg/kg 相比，EESIR 200mg/kg 产生的抗氧化活性更高（P<0.01）。EESIR 的高效液相色谱（HPLC）分析表明存在生物标志物没食子酸和槲皮素。总之，EESIR 具有抗 1 型糖尿病大鼠的抗糖尿病、抗高血脂和体内抗氧化活性。其抗氧化和降低血脂的作用有助于预防糖尿病并发症，这些作用可能是由于存在上述生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57ab/2952313/432fbe4e5359/ECAM2011-571721.009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57ab/2952313/e07ac5602017/ECAM2011-571721.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57ab/2952313/432fbe4e5359/ECAM2011-571721.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57ab/2952313/5e437e22bb01/ECAM2011-571721.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57ab/2952313/642a0223b943/ECAM2011-571721.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57ab/2952313/26a81243c3df/ECAM2011-571721.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57ab/2952313/b4357f82d9fe/ECAM2011-571721.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57ab/2952313/8d712ba8ce59/ECAM2011-571721.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57ab/2952313/fdf20e781a32/ECAM2011-571721.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57ab/2952313/4a94ae6fb53c/ECAM2011-571721.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57ab/2952313/e07ac5602017/ECAM2011-571721.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57ab/2952313/432fbe4e5359/ECAM2011-571721.009.jpg

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