Blumenkrantz N, Asboe-Hansen G
Scand J Rheumatol. 1978;7(2):123-7. doi: 10.3109/03009747809098849.
The effect on protocollagen proline hydroxylase of drugs reported to be capable of inducing the lupus erythematosus syndrome and in some way acting on connective tissue and inflammation was studied in an in vitro system for the hydroxylation of 14C-Pro-labelled protocollagen. Some derivatives were also studied. It was found that benzoic acid and phenothiazine derivatives, hydroxyphenols, (+)catechin, beta-amino propionitrile, certain B vitamins, dihydrazinophthalazine, cysteine and dimethylcysteine were inhibitors of PPH. The chelation of Fe2+ions by the compounds mentioned is suggested to be essential.
在一个用于14C-脯氨酸标记的原胶原蛋白羟化的体外系统中，研究了据报道能够诱发红斑狼疮综合征并以某种方式作用于结缔组织和炎症的药物对原胶原蛋白脯氨酸羟化酶的影响。还研究了一些衍生物。发现苯甲酸和吩噻嗪衍生物、羟基酚、（+）儿茶素、β-氨基丙腈、某些B族维生素、二肼酞嗪、半胱氨酸和二甲基半胱氨酸是原胶原蛋白脯氨酸羟化酶的抑制剂。所提及的化合物对Fe2+离子的螯合作用被认为是至关重要的。
