Effect of hydralazine and dihydralazine on connective tissue and binding to serum protein. - Suppr | 超能文献

Effect of hydralazine and dihydralazine on connective tissue and binding to serum protein.

作者信息

Blumenkrantz N, Christiansen A H, Asboe-Hansen G

出版信息

Scand J Rheumatol. 1979;8(3):177-83. doi: 10.3109/03009747909114452.

DOI:10.3109/03009747909114452

Abstract

Hydralazine and dihydralazine, chelators of Fe2+, Fe3+ and Mn2+ ions, inhibited collagen biosynthesis in organ culture of chicken embryo tibiae. Both substances inhibited the in vitro hydroxylation of [14C]Pro-labelled protocollagen by protocollagen proline hydroxylase. A decreased incorporation of [14C]-D-glucosamine into glyco- and/or muco-proteins was found under the effect of the two drugs. Dihydralazine, a cationic compound, was bound to DNA and acid mucopolysaccharides (glycosaminoglycans), forming an insoluble complex. Both substances were bound to serum alpha 2-globulin. Subcutaneous injections of dihydralazine in rats produced a local as well as a general toxic effect.

摘要

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