Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA.
Ann N Y Acad Sci. 2010 Oct;1207:41-5. doi: 10.1111/j.1749-6632.2010.05731.x.
Cerebrovascular disease is a major cause of death and disability, with a poorer outcome in patients having select risk factors including diabetes and hypertension. Risk factors and the state of cerebral ischemia-reperfusion associated with cerebrovascular occlusion are known to cause inflammatory changes. These events and the inflammatory state are reflected by transcript changes in various components of the blood and can be specifically measured. By defining these changes, new insight into cerebrovascular disease and its therapeutics is being achieved.
脑血管病是死亡和残疾的主要原因，患有包括糖尿病和高血压在内的特定危险因素的患者预后更差。已知与脑血管闭塞相关的危险因素和脑缺血再灌注状态会引起炎症变化。这些事件和炎症状态反映在血液的各种成分的转录变化中，可以进行特异性测量。通过定义这些变化，可以深入了解脑血管病及其治疗方法。
