Department of Stomatology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China (mainland).
Department of Anesthesiology, Chengdu Women' and Children's Central Hospital, Chengdu, Sichuan, China (mainland).
Med Sci Monit. 2018 Nov 13;24:8150-8159. doi: 10.12659/MSM.912784.
BACKGROUND The impact of hyperbaric oxygen (HBO) on the healing of soft tissues around dental implants was studied in a beagle model. MATERIAL AND METHODS Beagle dogs were randomized to receive implants, followed by postoperative HBO therapy or not (n=10 per group). On postoperative days 3, 7, and 14, tissue specimens were paraffin-embedded and analyzed by hematoxylin-eosin and Masson staining, as well as immunohistochemistry against CD31. RESULTS Scores for inflammation pathology based on hematoxylin-eosin staining and mean optical density of collagen fibers were significantly different between the HBO and control groups on postoperative days 3 and 7 (P<0.05), but not on day 14. Mean optical density due to anti-CD31 staining was significantly higher in the HBO group on postoperative days 3, 7, and 14 (P<0.05). CONCLUSIONS These results suggest that HBO may promote early osteogenesis and soft tissue healing after implantation.
本研究通过比格犬模型探讨高压氧（HBO）对牙种植体周围软组织愈合的影响。
将比格犬随机分为两组，每组 10 只，分别接受术后 HBO 治疗和不治疗。术后第 3、7、14 天，对组织标本进行石蜡包埋，采用苏木精-伊红染色和 Masson 染色，以及 CD31 免疫组化进行分析。
术后第 3、7 天，HBO 组与对照组的炎症病理学评分基于苏木精-伊红染色和胶原纤维平均光密度存在显著差异（P<0.05），但在第 14 天没有差异。术后第 3、7、14 天，HBO 组的抗 CD31 染色平均光密度明显更高（P<0.05）。
这些结果表明，HBO 可能促进种植术后早期成骨和软组织愈合。
