Department of Nutritional Medicine, Interactive Research School for Health Affairs, Bharati Vidyapeeth University, Pune 411043, India.
Prostaglandins Leukot Essent Fatty Acids. 2011 Sep-Oct;85(3-4):149-53. doi: 10.1016/j.plefa.2011.06.003. Epub 2011 Aug 4.
Reports suggest that the placenta in preterm birth may provide clues to predicting the risk of individuals developing chronic diseases in later life. Placental delivery of long chain polyunsaturated fatty acids (LCPUFA) (constituents of the cell membrane and precursors of prostaglandins) is essential for the optimal development of the central nervous system of the fetus. The present study examines the levels of LCPUFA and their association with placental weight and birth outcome in 58 women delivering preterm and 44 women delivering at term. Docosahexaenoic acid (DHA) and arachidonic acid (ARA) levels were lower (p<0.01) in women delivering preterm. There was a positive association of placental DHA with placental weight (p=0.036) and nervonic acid with head circumference (p=0.040) in the preterm group. Altered placental LCPUFA status exists in Indian mothers delivering preterm, which may influence the birth outcome.
报告表明，早产时的胎盘可能为预测个体日后罹患慢性疾病的风险提供线索。长链多不饱和脂肪酸（LCPUFA）（细胞膜的组成部分和前列腺素的前体）向胎盘的输送对于胎儿中枢神经系统的最佳发育至关重要。本研究检查了 58 名早产妇女和 44 名足月分娩妇女的 LCPUFA 水平及其与胎盘重量和分娩结局的关系。早产妇女的二十二碳六烯酸（DHA）和花生四烯酸（ARA）水平较低（p<0.01）。早产组中胎盘 DHA 与胎盘重量呈正相关（p=0.036），神经酸与头围呈正相关（p=0.040）。印度早产母亲的胎盘 LCPUFA 状况发生了改变，这可能会影响分娩结局。
