潜在的抗肿瘤剂XVII（1）。吲哚衍生物及其中间体的细胞毒性剂。
Potential antitumor agents XVII (1). Cytotoxic agents from indole derivatives and their intermediates.
作者信息
Andreani A, Rambaldi M, Locatelli A, Andreani F, Aresca P, Bossa R, Galatulas I
机构信息
Dipartimento di Scienze Farmaceutiche, University of Bologna, Italy.
出版信息
Acta Pharm Nord. 1990;2(6):407-14.
PMID:2095799
Abstract
New indole derivatives and their intermediates were tested as cytotoxic agents on a culture of P388 leukemia cells. The aldehyde 2a was more active than the thiosemicarbazones 3a, b and the nitrosourea 14. The chloroacetyl derivatives 10, 11 were the most potent cytotoxic agents.
摘要
新型吲哚衍生物及其中间体作为细胞毒性剂，在P388白血病细胞培养物上进行了测试。醛2a比硫代半卡巴腙3a、b和亚硝基脲14更具活性。氯乙酰衍生物10、11是最有效的细胞毒性剂。
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