Kimber I, Bentley A N, Hilton J
Immunology Group, ICI Central Toxicology Laboratory, Macclesfield, Cheshire, UK.
Contact Dermatitis. 1990 Nov;23(5):325-30. doi: 10.1111/j.1600-0536.1990.tb05166.x.
The ability of nickel sulphate and potassium dichromate to induce contact sensitization in mice has been investigated. Topical exposure of mice to 0.5% potassium dichromate in dimethylsulphoxide (DMSO) under occlusion resulted in specific contact sensitization in each of 7 experiments. Although sensitization to nickel sulphate under the same conditions was weak and somewhat variable, evidence for significant levels of contact allergy was obtained in 4 of 7 experiments. In addition, repeated topical application of both nickel sulphate and potassium dichromate in DMSO was found to result in the induction of lymphocyte proliferative responses in lymph nodes draining the site of exposure. These data indicate that epicutaneous exposure to both metal salts may cause specific contact sensitization in mice.
已对硫酸镍和重铬酸钾在小鼠中诱导接触性致敏的能力进行了研究。在封闭条件下，将小鼠局部暴露于二甲基亚砜（DMSO）中的0.5%重铬酸钾，在7个实验中的每一个实验中均导致了特异性接触性致敏。尽管在相同条件下对硫酸镍的致敏作用较弱且有些变化，但在7个实验中的4个实验中获得了显著水平接触性过敏的证据。此外，发现硫酸镍和重铬酸钾在DMSO中反复局部应用会导致暴露部位引流淋巴结中淋巴细胞增殖反应的诱导。这些数据表明，经皮暴露于这两种金属盐可能会在小鼠中引起特异性接触性致敏。
