Söderberg T A, Elmros T, Gref R, Hallmans G
Department of Hand Surgery, University Hospital of Umeå, Sweden.
Contact Dermatitis. 1990 Nov;23(5):346-51. doi: 10.1111/j.1600-0536.1990.tb05170.x.
Contact allergy to a wound dressing with an adhesive mass consisting of colophony, zinc oxide and rubber (Mezinc) was studied in 179 patients with a history of eczema. 12 patients were found to be allergic to colophony, whereas only 4 of these patients also showed a positive patch test reaction to the wound dressing. 14 patients with verified moderate contact allergy to colophony were patch tested with adhesive mass (10%), Portuguese colophony (10%), zinc oxide (10%), purified resin acids (10%), and Portuguese colophony (10%), in combination with zinc oxide. Only 3 patients reacted to the adhesive mass, whereas all patients showed a positive patch test reaction to Portuguese colophony. A combination of zinc oxide (10%) with Portuguese colophony (10%) provoked a positive patch test reaction in only 5 of these 14 patients. An allergic reaction to abietic acid (90-95% purity) was found in 7 patients and to neoabietic acid (99 + %) in 3 patients, whereas no reactions to dehydroabietic (99 + %), isopimaric (99 + %) or levopimaric acids (98 + %) were found.
对一种由松香、氧化锌和橡胶（Mezinc）组成的有粘性物质的伤口敷料进行接触性过敏研究，研究对象为179例有湿疹病史的患者。发现12例患者对松香过敏，而这些患者中只有4例对伤口敷料的斑贴试验也呈阳性反应。对14例已证实对松香有中度接触性过敏的患者，用粘性物质（10%）、葡萄牙松香（10%）、氧化锌（10%）、纯化树脂酸（10%）以及葡萄牙松香（10%）与氧化锌的混合物进行斑贴试验。只有3例患者对粘性物质有反应，而所有患者对葡萄牙松香的斑贴试验均呈阳性反应。在这14例患者中，只有5例对氧化锌（10%）与葡萄牙松香（10%）的混合物的斑贴试验呈阳性反应。7例患者对枞酸（纯度90 - 95%）有过敏反应，3例患者对新枞酸（纯度99 + %）有过敏反应，而对脱氢枞酸（纯度99 + %）、异海松酸（纯度99 + %）或左旋海松酸（纯度98 + %）未发现过敏反应。
