Jergovic Matijana, Miskulin Maja, Puntaric Dinko, Gmajnic Rudika, Milas Josip, Sipos Laszlo
Dr Andrija Štampar Institute of Public Health, Zagreb, Croatia.
Croat Med J. 2010 Oct;51(5):451-60. doi: 10.3325/cmj.2010.51.451.
To determine differences in metal and metalloid exposure between residents of areas in eastern Croatia exposed to heavy fighting during the war in Croatia and residents of areas exposed to moderate fighting.
Concentrations of aluminum (Al), arsenic (As), barium (Ba), cadmium (Cd), chromium (Cr), copper (Cu), iron (Fe), nickel (Ni), lead (Pb), uranium (U), vanadium (V), and zinc (Zn), reported to be associated with military operations, were determined in hair, serum, and urine samples using inductively-coupled plasma mass spectroscopy. A total of 127 and 46 participants from areas of heavy and moderate fighting, respectively, were included.
Compared with participants from areas exposed to moderate fighting, participants from areas exposed to heavy fighting had significantly higher serum concentrations of Al (87.61 vs 42.75 μg/L, P=0.007), As (5.05 ∓ 1.79 vs 4.16 ∓ 1.55 μg/L, P=0.003), Ba (7.12 vs 6.01 μg/L, P=0.044), and V (17.98 vs 16.84 μg/L, P=0.008); significantly higher urine concentrations of As (43.90 vs 11.51 μg/L, P<0.001) and Cd (0.67 vs 0.50 μg/L, P=0.031); and significantly higher hair concentrations of Al (12.61 vs 7.33 μg/L, P<0.001), As (0.32 vs 0.05 μg/L, P<0.001), Cd (0.03 vs 0.02 μg/L, P=0.002), Fe (22.58 vs 12.68 μg/L, P=0.001), Pb (1.04 vs 0.69 μg/L, P=0.006), and V (0.07 vs 0.03 μg/L, P<0.001).
Differences between populations from eastern Croatian areas exposed to heavy and populations exposed to moderate fighting point to the need for extensive monitoring of metal and metalloid exposure, emphasizing the role of biomonitoring through ecologic and preventive activities.
确定克罗地亚东部在克罗地亚战争期间遭受激烈战斗地区的居民与遭受中度战斗地区的居民在金属和类金属暴露方面的差异。
使用电感耦合等离子体质谱法测定头发、血清和尿液样本中据报道与军事行动相关的铝（Al）、砷（As）、钡（Ba）、镉（Cd）、铬（Cr）、铜（Cu）、铁（Fe）、镍（Ni）、铅（Pb）、铀（U）、钒（V）和锌（Zn）的浓度。分别纳入了来自激烈战斗地区和中度战斗地区的127名和46名参与者。
与来自中度战斗地区的参与者相比，来自激烈战斗地区的参与者血清中Al（87.61对42.75μg/L，P = 0.007）、As（5.05±1.79对4.16±1.55μg/L，P = 0.003）、Ba（7.12对6.01μg/L，P = 0.044）和V（17.98对16.84μg/L，P = 0.008）的浓度显著更高；尿液中As（43.90对11.51μg/L，P<0.001）和Cd（0.67对0.50μg/L，P = 0.031）的浓度显著更高；头发中Al（12.61对7.33μg/L，P<0.001）、As（0.32对0.05μg/L，P<0.001）、Cd（0.03对0.02μg/L，P = 0.002）、Fe（22.58对12.68μg/L，P = 0.001）、Pb（1.04对0.69μg/L，P = 0.006）和V（0.07对0.03μg/L，P<0.001）的浓度显著更高。
克罗地亚东部遭受激烈战斗地区的人群与遭受中度战斗地区的人群之间的差异表明需要对金属和类金属暴露进行广泛监测，强调通过生态和预防活动进行生物监测的作用。
