Department of Obstetrics and Gynecology, Al Basrah Maternity Hospital, Al Basrah Medical School, P.O. Box 1633, Basrah, Iraq.
Bull Environ Contam Toxicol. 2012 Nov;89(5):937-44. doi: 10.1007/s00128-012-0817-2. Epub 2012 Sep 16.
Between October 1994 and October 1995, the number of birth defects per 1,000 live births in Al Basrah Maternity Hospital was 1.37. In 2003, the number of birth defects in Al Basrah Maternity Hospital was 23 per 1,000 live births. Within less than a decade, the occurrence of congenital birth defects increased by an astonishing 17-fold in the same hospital. A yearly account of the occurrence and types of birth defects, between 2003 and 2011, in Al Basrah Maternity Hospital, was reported. Metal levels in hair, toenail, and tooth samples of residents of Al Basrah were also provided. The enamel portion of the deciduous tooth from a child with birth defects from Al Basrah (4.19 μg/g) had nearly three times higher lead than the whole teeth of children living in unimpacted areas. Lead was 1.4 times higher in the tooth enamel of parents of children with birth defects (2,497 ± 1,400 μg/g, mean ± SD) compared to parents of normal children (1,826 ± 1,819 μg/g). Our data suggested that birth defects in the Iraqi cities of Al Basrah (in the south of Iraq) and Fallujah (in central Iraq) are mainly folate-dependent. This knowledge offers possible treatment options and remediation plans for at-risk Iraqi populations.
在 1994 年 10 月至 1995 年 10 月期间，巴士拉妇产医院每 1000 例活产的出生缺陷数量为 1.37。2003 年，巴士拉妇产医院每 1000 例活产的出生缺陷数量为 23。在不到十年的时间里，同一医院先天性出生缺陷的发生率惊人地增加了 17 倍。报告了 2003 年至 2011 年巴士拉妇产医院出生缺陷的发生和类型的年度记录，并提供了巴士拉居民头发、脚趾甲和牙齿样本中的金属水平。来自巴士拉出生缺陷儿童的乳牙牙釉质部分（4.19μg/g）的铅含量几乎是生活在未受影响地区儿童全牙的三倍。有出生缺陷儿童的父母的牙齿牙釉质中的铅含量（2497±1400μg/g，平均值±标准差）比正常儿童的父母（1826±1819μg/g）高 1.4 倍。我们的数据表明，伊拉克巴士拉（伊拉克南部）和费卢杰（伊拉克中部）的城市的出生缺陷主要依赖于叶酸。这一知识为有风险的伊拉克人群提供了可能的治疗选择和补救计划。
