暴露于酸性药物的牙釉质的体外改变。

In vitro alterations in dental enamel exposed to acidic medicines.

机构信息

Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Federal University of Rio de Janeiro, RJ, Brazil.

出版信息

Int J Paediatr Dent. 2011 Mar;21(2):141-50. doi: 10.1111/j.1365-263X.2010.01104.x. Epub 2010 Oct 21.

DOI:10.1111/j.1365-263X.2010.01104.x

PMID:20961343

Abstract

OBJECTIVE

To evaluate the effect of acidic medicines (Klaricid(®), Claritin(®), and Dimetapp(®)) on surface enamel in vitro.

METHODS

Enamel blocks (n=104) were randomly distributed into two groups: G1 (pH-cycling simulating physiological oral conditions) and G2 (erosive conditions). Each group was divided into four subgroups, three to be immersed in the medicines and the control in deionized water. Specimen surfaces were evaluated for roughness and hardness at baseline and again after the in vitro experimental phase, which included 30 min immersions in the medicines twice daily for 12 days. Scanning electron microscopy (SEM) was also performed after the in vitro experimental phase.

RESULTS

All medicines produced a significant reduction in hardness in G1 after 12 days (P<0.05). The three medicines promoted greater roughness after both pH-regimens - G1 and G2 (P<0.01), except for Claritin in G1. Scanning electron microscopy analysis showed erosive patterns in all subgroups. Dimetapp(®) showed the most erosion and Klaricid(®) the least, in both groups.

CONCLUSION

Dimetapp(®) (lowest pH and viscosity) and deionized water (control) showed the most pronounced erosive patterns. Klaricid(®) (highest pH and viscosity) presented an in vitro protective effect against acid attacks perhaps due to its mineral content and viscosity.

摘要

目的

评估酸性药物（克拉仙®、开瑞坦®和速达菲®）对体外牙釉质的影响。

方法

将牙釉质块（n=104）随机分为两组：G1（模拟生理口腔条件的 pH 循环）和 G2（腐蚀性条件）。每组再分为四个亚组，其中三个亚组分别浸泡在药物中，对照组浸泡在去离子水中。在基线和体外实验阶段后再次评估标本表面的粗糙度和硬度，体外实验阶段包括每天两次将标本浸入药物中 30 分钟，持续 12 天。体外实验阶段后还进行了扫描电子显微镜（SEM）检查。

结果

所有药物在 12 天后均导致 G1 硬度显著降低（P<0.05）。在两种 pH 方案（G1 和 G2）下，三种药物均导致粗糙度增加（P<0.01），除 G1 中的开瑞坦®外。扫描电子显微镜分析显示所有亚组均存在侵蚀模式。在两组中，速达菲®（最低 pH 值和粘度）显示出最严重的侵蚀，而克拉仙®（最高 pH 值和粘度）则表现出体外抗酸攻击的保护作用，可能是由于其矿物质含量和粘度。