STAT3 是否可以在呼吸作用和细胞周期进展之间建立联系？
Could STAT3 provide a link between respiration and cell cycle progression?
机构信息
University of Nottingham, Queen's Medical Centre, Nottingham, UK.
出版信息
Cell Cycle. 2010 Nov 1;9(21):4294-6. doi: 10.4161/cc.9.21.13677. Epub 2010 Nov 10.
Abstract
Maintaining the intracellular environment is important for the survival and proliferation of eukaryotic cells. How a cell regulates its redox potential during fluctuations in the generation of intracellular reactive oxygen species and exposure to extracellular oxidants is unclear. The recent findings that Signal Transducer and Activator of Transcription 3 (STAT3) regulates mitochondrial respiration and can be oxidised directly by peroxide to form multimers may have revealed features of a homeostatic mechanism coupling cell cycle progression to the intracellular redox potential.
摘要
维持细胞内环境对于真核细胞的生存和增殖至关重要。在细胞内活性氧生成波动和暴露于细胞外氧化剂时，细胞如何调节其氧化还原电位尚不清楚。最近的研究发现，信号转导和转录激活因子 3（STAT3）调节线粒体呼吸，并且可以被过氧化物直接氧化形成多聚体，这可能揭示了一种将细胞周期进程与细胞内氧化还原电位偶联的稳态机制的特征。
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