Department of Kinesiology, Women's Health and Exercise Laboratory, Noll Laboratories, Penn State University, University Park, PA 16802, USA.
Appl Physiol Nutr Metab. 2010 Oct;35(5):573-82. doi: 10.1139/H10-046.
Chronic inflammation has been implicated in the pathogenesis of several chronic diseases, such as atherosclerosis and diabetes, as well as certain types of cancers. It has been suggested that circulating biomarkers for inflammation may be modified by exercise; however, few laboratory-based studies have been conducted in nonobese premenopausal women. The purpose of this investigation was to determine the impact of a 4-month exercise training and caloric-restriction intervention with the goal of weight loss on circulating biomarkers of inflammation in sedentary premenopausal women aged 25- 40 years (weight, 57 ± 2 kg). Subjects were studied for 6 consecutive menstrual cycles: 1 Screening, 1 Baseline, then 4 interventions (Interventions 1-4). Supervised aerobic training, consisting primarily of treadmill running and elliptical machine exercise, was performed 4 times per week for 40-90 min at 79% ± 0.7% of maximal heart rate. Subjects also consumed 30% fewer calories vs. baseline (1863 ± 58 to 1428 ± 53 kcalday(-1) (1 kcal = 4.186 kJ), p < 0.0001). Circulating inflammatory biomarkers, including adiponectin, high-sensitivity (hs) C-reactive protein (CRP), tumour necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interferon-gamma (IFN-γ), and leptin, as well as body composition, aerobic capacity, and energy balance, were measured before and after the intervention. Maximal aerobic capacity increased by 8.5 ± 1.7 mL kg(-1)min-1 (p < 0.001) and body mass declined by an average of 3.7 ± 0.5 kg (p < 0.001). Significant reductions in IL-6 (0.39 ± 0.04 to 0.30 ± 0.03 pgmL(-1), p = 0.025), IFN-γ (0.58 ± 0.83 to 0.42 ± 0.64 pgmL-1, p = 0.030), and leptin (13.18 ± 1.28 to 6.28 ± 0.71 pgmL(-1), p < 0.001) were detected in response to the intervention. No significant changes in adiponectin, hs-CRP, or TNF-α were found. Weight loss in response to exercise training and caloric restriction is effective in reducing inflammatory markers, specifically IL-6 and leptin.
慢性炎症与几种慢性疾病的发病机制有关，如动脉粥样硬化和糖尿病以及某些类型的癌症。有研究表明，炎症的循环生物标志物可能会因运动而改变；然而，在非肥胖绝经前妇女中进行的基于实验室的研究很少。本研究的目的是确定为期 4 个月的运动训练和热量限制干预（目标是减肥）对 25-40 岁久坐绝经前女性（体重 57 ± 2kg）循环炎症生物标志物的影响。研究对象连续 6 个月经周期进行研究：1 个筛查，1 个基线，然后是 4 个干预（干预 1-4）。监督性有氧运动主要由跑步机跑步和椭圆机运动组成，每周进行 4 次，每次 40-90 分钟，达到最大心率的 79%±0.7%。与基线相比，受试者还摄入了 30%的热量（1863±58 至 1428±53kcal·天(-1)（1kcal=4.186kJ），p<0.0001）。循环炎症生物标志物，包括脂联素、高敏（hs）C 反应蛋白（CRP）、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、干扰素-γ（IFN-γ）和瘦素，以及身体成分、有氧能力和能量平衡，在干预前后进行了测量。最大有氧能力增加了 8.5±1.7mL·kg(-1)·min(-1)（p<0.001），体重平均下降了 3.7±0.5kg（p<0.001）。IL-6（0.39±0.04 至 0.30±0.03pg·mL(-1)，p=0.025）、IFN-γ（0.58±0.83 至 0.42±0.64pg·mL(-1)，p=0.030）和瘦素（13.18±1.28 至 6.28±0.71pg·mL(-1)，p<0.001）的水平显著降低。脂联素、hs-CRP 或 TNF-α没有明显变化。运动训练和热量限制引起的体重减轻可有效降低炎症标志物，特别是 IL-6 和瘦素。
