Department of Chemistry, University of California, Berkeley, California 94720, United States.
Langmuir. 2010 Nov 16;26(22):17383-8. doi: 10.1021/la1039305. Epub 2010 Oct 21.
We have developed a method for integrating the self-assembling tobacco mosaic virus capsid into hydrophobic solvents and hydrophobic polymers. The capsid was modified at tyrosine residues to display an array of linear poly(ethylene glycol) chains, allowing it to be transferred into chloroform. In a subsequent step, the capsids could be transferred to a variety of hydrophobic solvents, including benzyl alcohol, o-dichlorobenzene, and diglyme. The thermal stability of the material against denaturation increased from 70 °C in water to at least 160 °C in hydrophobic solvents. With a view toward material fabrication, the polymer-coated TMV rods were also incorporated into solid polystyrene and thermally cast at 110 °C. Overall, this process significantly expands the range of processing conditions for TMV-based materials, with the goal of incorporating these templated nanoscale systems into conductive polymer matrices.
我们开发了一种将烟草花叶病毒衣壳自组装体整合到疏溶剂和疏聚物中的方法。衣壳在酪氨酸残基处被修饰以展示一系列线性聚（乙二醇）链，从而能够转移到氯仿中。在随后的步骤中，衣壳可以转移到各种疏溶剂中，包括苄醇、邻二氯苯和二甘醇。材料对变性的热稳定性从水中的 70°C 增加到疏溶剂中的至少 160°C。为了进行材料制造，聚合物涂覆的 TMV 棒也被掺入固体聚苯乙烯中，并在 110°C 下进行热铸。总体而言，该过程显著扩展了 TMV 基材料的处理条件范围，目的是将这些模板纳米级系统纳入导电聚合物基质中。
