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高效微波辅助合成 5-脱氮黄素衍生物。

Efficient microwave-assisted synthesis of 5-deazaflavine derivatives.

机构信息

Grupo de Investigación en Compuestos Heterocíclicos, Programa de Química, Facultad de Ciencias Básicas, Universidad del Atlántico, A.A.1890 Barranquilla, Colombia.

出版信息

Molecules. 2010 Oct 20;15(10):7227-34. doi: 10.3390/molecules15107227.

DOI:10.3390/molecules15107227
PMID:20966872
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6259259/
Abstract

A series of pyrimido[4,5-b]quinolines (5-deazaflavines), were synthesized by microwave assisted intramolecular cyclization. The N⁴-substituted-2,4-diamino-6-chloro-pyrimidine-5-carbaldehydes, were prepared by selective monoamination of 2-amino-4,6-dichloropyrimidine-5-carbaldehyde with aliphatic and aromatic amines.

摘要

一系列嘧啶并[4,5-b]喹啉（5-氮杂黄酮）通过微波辅助的分子内环化反应合成。N⁴-取代的 2,4-二氨基-6-氯嘧啶-5-甲酰基醛通过 2-氨基-4,6-二氯嘧啶-5-甲酰基醛与脂肪族和芳香族胺的选择性单胺化反应制备。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ffe/6259259/0c67d3aa20c5/molecules-15-07227-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ffe/6259259/8d083cfbf545/molecules-15-07227-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ffe/6259259/9b4b8897fcc8/molecules-15-07227-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ffe/6259259/9f28cc8c3b31/molecules-15-07227-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ffe/6259259/0c67d3aa20c5/molecules-15-07227-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ffe/6259259/8d083cfbf545/molecules-15-07227-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ffe/6259259/9b4b8897fcc8/molecules-15-07227-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ffe/6259259/9f28cc8c3b31/molecules-15-07227-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ffe/6259259/0c67d3aa20c5/molecules-15-07227-g004.jpg

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