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本文引用的文献

1
Optical coherence tomography features of x-linked choroideremia.X连锁遗传性视网膜色素变性的光学相干断层扫描特征
Retin Cases Brief Rep. 2009 Spring;3(2):180-2. doi: 10.1097/ICB.0b013e31816bbee9.
2
Correlation between fluorescein angiography and spectral-domain optical coherence tomography in the diagnosis of cystoid macular edema.荧光素血管造影与频域光相干断层扫描在诊断囊样黄斑水肿中的相关性。
Br J Ophthalmol. 2010 Sep;94(9):1197-200. doi: 10.1136/bjo.2009.170589. Epub 2009 Dec 3.
3
Choroideremia: new findings from ocular pathology and review of recent literature.无脉络膜症：眼病理学的新发现及近期文献综述
Surv Ophthalmol. 2009 May-Jun;54(3):401-7. doi: 10.1016/j.survophthal.2009.02.008.
4
A hereditary and clinical study of choroideremia.无脉络膜症的遗传与临床研究。
Trans Am Acad Ophthalmol Otolaryngol. 1948 Jan-Feb;52:160-90.
5
Prevalence of cystic macular lesions in patients with Usher II syndrome.Usher II 综合征患者的囊样黄斑病变患病率。
Eye (Lond). 2009 May;23(5):1206-9. doi: 10.1038/eye.2008.105. Epub 2008 Apr 18.
6
The prevalence of cystoid macular oedema on optical coherence tomography in retinitis pigmentosa patients without cystic changes on fundus examination.在眼底检查无囊样改变的色素性视网膜炎患者中，光学相干断层扫描检查出的黄斑囊样水肿的患病率。
Eye (Lond). 2009 Apr;23(4):915-9. doi: 10.1038/eye.2008.110. Epub 2008 Apr 18.
7
Prevalence of cystoid macular edema and stability in oct retinal thickness in eyes with retinitis pigmentosa during a 48-week lutein trial.在一项为期48周的叶黄素试验中，视网膜色素变性患者黄斑囊样水肿的患病率及黄斑区视网膜厚度的稳定性。
Retina. 2008 Jan;28(1):103-10. doi: 10.1097/IAE.0b013e31809862aa.
8
Macular edema associated with gyrate atrophy managed with intravitreal triamcinolone: a case report.玻璃体内注射曲安奈德治疗与视网膜色素变性相关的黄斑水肿：一例报告
Arq Bras Oftalmol. 2007 Sep-Oct;70(5):858-61. doi: 10.1590/s0004-27492007000500024.
9
Clinical and functional findings in choroideremia due to complete deletion of the CHM gene.由于CHM基因完全缺失导致的无脉络膜症的临床和功能表现。
Arch Ophthalmol. 2007 Aug;125(8):1107-13. doi: 10.1001/archopht.125.8.1107.
10
Remodeling of the human retina in choroideremia: rab escort protein 1 (REP-1) mutations.脉络膜视网膜炎患者视网膜重塑：rab护送蛋白1（REP-1）突变
Invest Ophthalmol Vis Sci. 2006 Sep;47(9):4113-20. doi: 10.1167/iovs.06-0424.

脉络膜视网膜变性患者眼底检查未见囊样改变，但频域光相干断层扫描可见囊样黄斑水肿。

Cystic macular oedema on spectral-domain optical coherence tomography in choroideremia patients without cystic changes on fundus examination.

机构信息

Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL 60612-7234, USA.

出版信息

Eye (Lond). 2011 Jan;25(1):84-90. doi: 10.1038/eye.2010.157. Epub 2010 Oct 22.

DOI:10.1038/eye.2010.157
PMID:20966974
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3020991/
Abstract

PURPOSE

To determine the prevalence of cystic macular oedema (CME) in patients with choroideremia (CHM) by using spectral-domain optical coherence tomography (SD-OCT).

METHODS

A total 16 patients affected with CHM were enrolled in the study. All patients underwent a complete eye examination. SD-OCT was performed using an OPKO spectral-domain OCT/SLO instrument.

RESULTS

The average age of the study patients was 44.0 ± 16.0 years (range, 13-63 years). Out of the 16 patients with CHM, 10 patients (62.5%) showed a degree of CME on SD-OCT testing in at least one eye, and 8 patients (50%) showed CME in both eyes.

CONCLUSIONS

Because of its notable prevalence, it would seem prudent to screen CHM patients by SD-OCT for the possible presence of CME and to identify those amenable to future treatment strategies for their macular oedema.

摘要

目的

通过频域光学相干断层扫描（SD-OCT）确定脉络膜视网膜变性（CHM）患者中囊样黄斑水肿（CME）的患病率。

方法

本研究纳入了 16 名患有 CHM 的患者。所有患者均接受了全面的眼部检查。使用 OPKO 频域 OCT/SLO 仪器进行 SD-OCT 检查。

结果

研究患者的平均年龄为 44.0±16.0 岁（范围，13-63 岁）。在 16 名患有 CHM 的患者中，有 10 名（62.5%）在至少一只眼中的 SD-OCT 检查中显示出一定程度的 CME，有 8 名（50%）在两只眼中均显示出 CME。

结论

鉴于其显著的患病率，通过 SD-OCT 对 CHM 患者进行 CME 筛查并确定那些对未来黄斑水肿治疗策略有反应的患者似乎是明智的。