Vasconcelos-Santos Daniel Vítor, Magalhães Erika Pacheco, Nehemy Márcio Bittar
Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Arq Bras Oftalmol. 2007 Sep-Oct;70(5):858-61. doi: 10.1590/s0004-27492007000500024.
To describe the use of 4 mg intravitreal triamcinolone acetonide (IVTA) for gyrate atrophy-related macular edema (ME) and to report anatomic and functional outcomes, during a nine-month period.
A 27-year-old female complained of decreased vision since diagnosis of gyrate athrophy (GA), six years before admission. At presentation visual acuity was 20/100 in OD and 20/80 in OS. Ophthalmological examination disclosed significant cataract in OD, pseudophakia in OS and typical GA findings. Fluorescein angiography (FA) disclosed ME that was confirmed by optical coherence tomography (OCT), which also showed subfoveal fluid. OS was treated with a 4-mg IVTA injection. One month later, vision improved to 20/50+1 and foveal thickness decreased, with less leakage in FA. This picture was maintained up to six months, when there was recurrence of ME to a level similar to the baseline. At nine months, visual acuity dropped to 20/80, and ME was maintained, with remodeling in macular profile.
There is a transient therapeutic effect with 4-mg IVTA injection for GA-related ME. After drug clearance, edema recurs, with return of visual acuity to pretreatment level.
描述在九个月期间使用4毫克玻璃体内注射曲安奈德（IVTA）治疗视网膜色素变性相关黄斑水肿（ME）的情况，并报告解剖学和功能结果。
一名27岁女性自六年前被诊断为视网膜色素变性（GA）以来，视力逐渐下降。就诊时，右眼视力为20/100，左眼视力为20/80。眼科检查发现右眼有明显白内障，左眼为人工晶状体眼，并伴有典型的GA表现。荧光素血管造影（FA）显示有黄斑水肿，光学相干断层扫描（OCT）证实了这一点，OCT还显示了黄斑下积液。左眼接受了4毫克IVTA注射治疗。一个月后，视力提高到20/50+1，黄斑中心凹厚度减小，FA显示渗漏减少。这种情况持续了六个月，之后黄斑水肿复发至基线水平。九个月时，视力降至20/80，黄斑水肿持续存在，黄斑形态发生重塑。
4毫克IVTA注射对GA相关的黄斑水肿有短暂的治疗效果。药物清除后，水肿复发，视力恢复到治疗前水平。
