3-氨基-6-羟基-2-哌啶酮（Ahp）环二肽和蛋白酶抑制剂 Symplocamide A 的固相全合成。
Solid phase total synthesis of the 3-amino-6-hydroxy-2-piperidone (Ahp) cyclodepsipeptide and protease inhibitor Symplocamide A.
机构信息
Chemical Genomics Centre der Max-Planck-Gesellschaft, Otto-Hahn-Str. 15, 44227 Dortmund, Germany.
出版信息
Chem Commun (Camb). 2010 Dec 14;46(46):8857-9. doi: 10.1039/c0cc02889d. Epub 2010 Oct 22.
PMID:20967347
Abstract
The solid phase total synthesis of the marine cyanobacterial Ahp-cyclodepsipeptide Symplocamide A is reported as a model for a general route for the synthesis of tailor-made non-covalent serine protease inhibitors.
摘要
本文报道了海洋蓝细菌 Ahp-cyclodepsipeptide Symplocamide A 的固相全合成，为定制非共价丝氨酸蛋白酶抑制剂的通用合成路线提供了模型。
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