Nolph K D, Prowant B F, Moore H L, Reyad S E
Department of Medicine, University of Missouri Health Sciences Center, Columbia.
Perit Dial Int. 1990;10(4):279-82.
In a recent report, the relationship between renal creatinine clearance and hematocrit in patients with renal creatinine clearances, ranging from 55 to 8 mL per min. per 1.73 square meters of body surface area, was analyzed. The authors of this study have performed a cross-sectional analysis of the relationship of hematocrit to residual renal creatinine clearance in patients on continuous ambulatory peritoneal dialysis (CAPD). The authors of this study wanted to examine whether or not these hematocrits fall within extrapolations of the published 95% confidence limits for males and females with renal failure prior to end-stage renal disease and dialytic intervention. Authors also compared regression intercepts at residual creatinine clearances of 0. Most of the CAPD patients had hematocrits within the upper half or above the extrapolated 95% confidence limits for the predialysis population. Within the CAPD population, there were no significant correlations of hematocrit with residual creatinine clearance at these lower ranges. The degree of scatter in the CAPD population for hematocrit values was similar to that in the predialysis population. Residual creatinine clearance appears to be a crude index of the increasing severity of multiple factors that may contribute to the anemia. CAPD appears to maintain or improve hematocrit as renal mass and function decline.
在最近一份报告中，分析了每1.73平方米体表面积的肾肌酐清除率在每分钟55至8毫升范围内的患者的肾肌酐清除率与血细胞比容之间的关系。本研究的作者对持续非卧床腹膜透析（CAPD）患者的血细胞比容与残余肾肌酐清除率之间的关系进行了横断面分析。本研究的作者想要检查这些血细胞比容是否落在终末期肾病和透析干预之前已发表的肾衰竭男性和女性95%置信限的外推范围内。作者还比较了残余肌酐清除率为0时的回归截距。大多数CAPD患者的血细胞比容处于透析前人群外推的95%置信限的上半部分或以上。在CAPD人群中，在这些较低范围内，血细胞比容与残余肌酐清除率之间没有显著相关性。CAPD人群中血细胞比容值的离散程度与透析前人群相似。残余肌酐清除率似乎是可能导致贫血的多种因素严重程度增加的一个粗略指标。随着肾质量和功能下降，CAPD似乎能维持或改善血细胞比容。
