调控树突状细胞定型和发育的机制。
Mechanisms regulating dendritic cell specification and development.
机构信息
Department of Immunology and Center for Cancer Immunology Research, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.
出版信息
Immunol Rev. 2010 Nov;238(1):76-92. doi: 10.1111/j.1600-065X.2010.00949.x.
Abstract
Understanding the diversification of dendritic cell (DC) lineages is one of the last frontiers in mapping the developmental hierarchy of the hematopoietic system. DCs are a vital link between the innate and adaptive immune responses; thus, elucidating their developmental pathways is crucial for insight into the generation of natural immunity and for learning how to regulate DCs in clinical settings. DCs arise from hematopoietic stem cells through specialized progenitor subsets under the direction of FMS-like tyrosine kinase 3 ligand (Flt3L) and Flt3L receptor (Flt3) signaling. Recent studies have revealed important contributions from granulocyte-macrophage colony-stimulating factor (GM-CSF) and type I interferons (IFNs) in vivo. Furthermore, DC development is guided by lineage-restricted transcription factors such as IRF8, E2-2, and Batf3. A critical question centers on how cytokines and lineage-restricted transcription factors operate molecularly to direct DC diversification. Here, we review recent findings that provide new insight into the DC developmental process.
摘要
了解树突状细胞 (DC) 谱系的多样化是绘制造血系统发育层次结构的最后前沿之一。DC 是先天免疫和适应性免疫反应之间的重要纽带；因此，阐明其发育途径对于深入了解天然免疫的产生以及了解如何在临床环境中调节 DC 至关重要。DC 由造血干细胞通过在 FMS 样酪氨酸激酶 3 配体 (Flt3L) 和 Flt3L 受体 (Flt3) 信号的指导下通过专门的祖细胞亚群产生。最近的研究揭示了粒细胞-巨噬细胞集落刺激因子 (GM-CSF) 和 I 型干扰素 (IFN) 在体内的重要贡献。此外，DC 的发育受到谱系特异性转录因子（如 IRF8、E2-2 和 Batf3）的指导。一个关键问题集中在细胞因子和谱系特异性转录因子如何在分子水平上运作以指导 DC 多样化。在这里，我们回顾了最近的发现，这些发现为 DC 发育过程提供了新的见解。
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