Mansoura Urology and Nephrology Center, Urology Department, Mansoura, Egypt.
Int J Urol. 2010 Dec;17(12):964-73. doi: 10.1111/j.1442-2042.2010.02643.x. Epub 2010 Oct 24.
To overcome problems of damaged urinary tract tissues and complications of current procedures, tissue engineering (TE) techniques and stem cell (SC) research have achieved great progress. Although diversity of techniques is used, urologists should know the basics. We carried out a literature review regarding the basic principles and applications of TE and SC technologies in the genitourinary tract. We carried out MEDLINE/PubMed searches for English articles until March 2010 using a combination of the following keywords: bladder, erectile dysfunction, kidney, prostate, Peyronie's disease, stem cells, stress urinary incontinence, testis, tissue engineering, ureter, urethra and urinary tract. Retrieved abstracts were checked, and full versions of relevant articles were obtained. Scientists have achieved great advances in basic science research. This is obvious by the tremendous increase in the number of publications. We divided this review in two topics; the first discusses basic science principles of TE and SC, whereas the second part delineates current clinical applications and advances in urological literature. TE and SC applications represent an alternative resource for treating complicated urological diseases. Despite the paucity of clinical trials, the promising results of animal models and continuous work represents the hope of treating various urological disorders with this technology.
为了克服受损的泌尿道组织问题和当前治疗方法的并发症，组织工程（TE）技术和干细胞（SC）研究已经取得了很大进展。尽管使用了多种技术，但泌尿科医生应该了解其基础知识。我们对 TE 和 SC 技术在泌尿生殖系统中的基本原理和应用进行了文献回顾。我们使用 MEDLINE/PubMed 进行了英文文章的搜索，截至 2010 年 3 月，使用了以下关键词的组合：膀胱、勃起功能障碍、肾脏、前列腺、佩罗尼氏病、干细胞、压力性尿失禁、睾丸、组织工程、输尿管、尿道和泌尿道。检查了检索到的摘要，并获得了相关文章的全文。科学家们在基础科学研究方面取得了巨大的进步。出版物数量的大幅增加就证明了这一点。我们将这篇综述分为两个主题；第一部分讨论 TE 和 SC 的基础科学原理，第二部分阐述了当前在泌尿科文献中的临床应用和进展。TE 和 SC 的应用为治疗复杂的泌尿科疾病提供了一种替代资源。尽管临床试验较少，但动物模型的有前景的结果和不断的工作代表了用这项技术治疗各种泌尿科疾病的希望。
