多样性分子的多样角色：MHC 类 Ib 分子在宿主防御和自身免疫控制中的作用。
Diverse roles of non-diverse molecules: MHC class Ib molecules in host defense and control of autoimmunity.
机构信息
Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, United States.
出版信息
Curr Opin Immunol. 2011 Feb;23(1):104-10. doi: 10.1016/j.coi.2010.09.009. Epub 2010 Oct 21.
Abstract
While the prime function of classical MHC class I molecules (MHC-I) is to present peptide antigens to pathogen-specific cytotoxic T cells, non-classical MHC-I antigens perform a diverse array of functions in both innate and adaptive immunity. In this review we summarize recent evidence that non classical MHC-I molecules are not only recognized by pathogen-specific T cells but that they also serve as immunoregulatory molecules by stimulating a number of distinct non-conventional T cell subsets.
摘要
虽然经典 MHC I 类分子（MHC-I）的主要功能是将肽抗原呈递给病原体特异性细胞毒性 T 细胞，但非经典 MHC-I 抗原在先天和适应性免疫中发挥着多种多样的功能。在这篇综述中，我们总结了最近的证据，表明非经典 MHC-I 分子不仅被病原体特异性 T 细胞识别，而且还通过刺激许多不同的非常规 T 细胞亚群作为免疫调节分子发挥作用。
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