Department of Psychology, University of Southern California, Los Angeles, CA 90089-1061, USA.
Behav Genet. 2010 Nov;40(6):768-75. doi: 10.1007/s10519-010-9407-4. Epub 2010 Oct 24.
Thirty same-sex twin pairs were identified in which both members were assessed at baseline and one twin subsequently developed dementia, at least 3 years subsequent to the baseline measurement, while the partner remained cognitively intact for at least three additional years. Eighteen of the 30 cases were diagnosed with Alzheimer's disease. Baseline assessments, conducted when twins' average age was 70.6 (SD = 6.8), included a mailed questionnaire and in-person testing. Which twin would develop dementia was predicted by less favorable lipid values (higher apoB, ratio of apoB to apoA1, and total cholesterol), poorer grip strength, and-to a lesser extent-higher emotionality on the EAS Temperament Scale. Given the long preclinical period that characterizes Alzheimer's disease, these findings may suggest late life risk factors for dementia, or may reflect changes that are part of preclinical disease.
研究共鉴定出 30 对同性别双胞胎，这些双胞胎中的成员均在基线时接受了评估，其中一名双胞胎随后在基线测量至少 3 年后发展为痴呆症，而其伴侣在至少另外 3 年内认知功能完整。在 30 个病例中，有 18 个被诊断为阿尔茨海默病。在双胞胎平均年龄为 70.6 岁（标准差=6.8）时进行了基线评估，包括邮寄问卷和面对面测试。根据 EAS 气质量表的评估，载脂蛋白 B（apoB）较高、apoB 与 apoA1 的比值较高、总胆固醇较高、握力较差的双胞胎更容易发展为痴呆症。鉴于阿尔茨海默病具有较长的临床前期，这些发现可能提示痴呆症的晚年风险因素，或者可能反映了处于临床前期疾病的变化。
