Sharma S, Narula R, Nath R, Thind S K
Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
J Nutr Sci Vitaminol (Tokyo). 1990 Dec;36(6):579-86. doi: 10.3177/jnsv.36.579.
The intestinal uptake of [14C]oxalate, [14C]glyoxylate, and [14C]glycolate are studied in brush border membrane vesicles (BBMV) isolated from vitamin A-deficient and pair-fed control rats. The data obtained indicate that oxalate and its precursors are transported across the BBMV by passive diffusion. The intestinal uptake of glyoxylate and glycolate remains unaltered in vitamin A deficiency, while uptake rate of oxalate was significantly increased (p less than 0.01) in vitamin A-deficient rats as compared to pair-fed controls. In conclusion, the results indicate that vitamin A deficiency leads to hyperabsorption of oxalate through the gut.
在从维生素A缺乏和配对喂养的对照大鼠中分离出的刷状缘膜囊泡（BBMV）中，研究了[14C]草酸盐、[14C]乙醛酸盐和[14C]乙醇酸盐的肠道摄取情况。所获得的数据表明，草酸盐及其前体通过被动扩散穿过BBMV。在维生素A缺乏的情况下，乙醛酸盐和乙醇酸盐的肠道摄取没有变化，而与配对喂养的对照组相比，维生素A缺乏的大鼠中草酸盐的摄取率显著增加（p小于0.01）。总之，结果表明维生素A缺乏会导致草酸盐通过肠道的过度吸收。
