Gupta R, Sidhu H, Rattan V, Thind S K, Nath R
Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Biochem Med Metab Biol. 1988 Apr;39(2):190-8. doi: 10.1016/0885-4505(88)90076-x.
Acute, subclinical, and chronic pyridoxine deficiency did not modify the oxalate influx in rat intestinal BBMV but elevated the oxalate reabsorption by renal tubular cells. The Na+ and K+ ions did not affect oxalate uptake in either intestinal or renal BBMV. Although thiol group blocking agents did not affect intestinal uptake of oxalate they significantly altered oxalate translocation across the renal tubular cells. Following pyridoxine deficiency the rat kidneys appear to be more specific for inducing oxalate lithiasis as compared to oxalate influx through the intestine.
急性、亚临床和慢性吡哆醇缺乏症并未改变大鼠肠刷状缘膜囊泡（BBMV）中的草酸盐流入，但提高了肾小管细胞对草酸盐的重吸收。钠离子和钾离子对肠或肾BBMV中的草酸盐摄取均无影响。尽管巯基阻断剂不影响肠道对草酸盐的摄取，但它们显著改变了草酸盐在肾小管细胞中的转运。与通过肠道的草酸盐流入相比，吡哆醇缺乏后，大鼠肾脏似乎对诱导草酸盐结石形成更具特异性。
