两种 RTvue 光学相干断层扫描仪视网膜神经纤维层厚度测量模式的比较。
Comparison of two retinal nerve fibre layer thickness measurement patterns of RTvue optical coherence tomography.
机构信息
Beijing Ophthalmology and Visual Science Laboratory, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University Ophthalmology Department of Nanjing Tongren Hospital, Nanjing, China.
出版信息
Clin Exp Ophthalmol. 2011 Apr;39(3):222-9. doi: 10.1111/j.1442-9071.2010.02438.x.
BACKGROUND
To evaluate the agreement and repeatability between operator-dependent centring and automatic centring retinal nerve fibre layer thickness measurement patterns (RNFL3.45 and NHM4) of RTvue optical coherence tomography in normal and glaucomatous eyes.
DESIGN
Cross-sectional observational study.
PARTICIPANTS
A total of 153 eyes from 149 normal subjects and subjects with glaucoma were analysed.
METHODS
The retinal nerve fibre layer thickness was measured using RNFL3.45 and NHM4 three times on the same day to determine the repeatability and agreement between the two scan patterns.
MAIN OUTCOME MEASURES
Student's paired t-testing, intra-class correlation coefficient, coefficient of variation, test-retest viability, Pearson's correlation coefficient and Bland-Altman analysis of retinal nerve fibre layer thickness measurements.
RESULTS
The difference between RNFL3.45 and NHM4 measurements was statistically significant by paired t-testing (P=0.003) only in severe glaucoma group. The Pearson's correlation test showed a high degree of correlation of the mean retinal nerve fibre layer thickness (r=0.949). Bland-Altman plots showed that the differences between RNFL3.45 and NHM4 were smaller at thicker retinal nerve fibre layer values, but larger at thinner retinal nerve fibre layer values. The intra-class correlation coefficient for RNFL3.45 (and lower 95% confidence interval) in normal and glaucomatous eyes was 0.990 (0.985 confidence interval) and 0.997 (0.995 confidence interval), respectively. The intra-class correlation coefficient for NHM4 in normal and glaucomatous eyes was 0.989 (0.983 confidence interval) and 0.995 (0.992 confidence interval), respectively. The test-retest variability for RNFL3.45 and NHM4 ranged from 3.98 to 9.75µm in normal eyes, and from 4.10 to 13.34µm in glaucomatous eyes.
CONCLUSION
Measurements of retinal nerve fibre layer thickness by RNFL3.45 and NHM4 are in good agreement.
背景
评估 RTvue 光学相干断层扫描仪（OCT）中 operator-dependent 中心定位和自动中心定位视网膜神经纤维层厚度测量模式（RNFL3.45 和 NHM4）在正常眼和青光眼眼中的一致性和可重复性。
设计
横断面观察性研究。
参与者
共分析了 149 名正常受试者和青光眼受试者的 153 只眼。
方法
使用 RNFL3.45 和 NHM4 在同一天对视网膜神经纤维层厚度进行三次测量，以确定两种扫描模式之间的重复性和一致性。
主要观察指标
学生配对 t 检验、组内相关系数、变异系数、测试-再测试可行性、Pearson 相关系数和视网膜神经纤维层厚度测量的 Bland-Altman 分析。
结果
仅在严重青光眼组中，RNFL3.45 和 NHM4 测量值的差异通过配对 t 检验具有统计学意义（P=0.003）。Pearson 相关检验显示平均视网膜神经纤维层厚度具有高度相关性（r=0.949）。Bland-Altman 图显示，在较厚的视网膜神经纤维层值时，RNFL3.45 和 NHM4 之间的差异较小，但在较薄的视网膜神经纤维层值时，差异较大。正常眼和青光眼眼中，RNFL3.45 的组内相关系数（置信区间较低）分别为 0.990（置信区间为 0.985）和 0.997（置信区间为 0.995）。正常眼和青光眼眼中 NHM4 的组内相关系数分别为 0.989（置信区间为 0.983）和 0.995（置信区间为 0.992）。RNFL3.45 和 NHM4 的测试-再测试变异性在正常眼中范围为 3.98 至 9.75µm，在青光眼眼中范围为 4.10 至 13.34µm。
结论
RNFL3.45 和 NHM4 测量的视网膜神经纤维层厚度具有良好的一致性。
Zotero 插件