Department of Medical Microbiology and Infection Control, VUMC Amsterdam, The Netherlands.
Epidemiol Infect. 2011 Sep;139(9):1361-8. doi: 10.1017/S0950268810002359. Epub 2010 Oct 26.
The annual number of episodes of clinical gastroenteritis caused by Campylobacter spp. in The Netherlands is estimated to be 75 000, i.e. once per 200 person life-years. This number is based on extrapolation of culture results from population-based studies. The number of culture-confirmed cases of Campylobacter infection peaks in the first 3 years of life and again between the ages of 20 and 25 years. The seroepidemiology of Campylobacter describes the relationship between age and exposure to Campylobacter and reflects both symptomatic and asymptomatic infections. Using a validated ELISA system, antibodies to Campylobacter were measured in an age-stratified sample (n=456) of the PIENTER serum collection of the Dutch general population. The seroprevalence of Campylobacter IgG antibodies increased with age, reaching almost 100% at age 20 years. Antibody levels steadily increased with age until young adulthood, suggesting repeated exposure to Campylobacter. In conclusion, seroepidemiological data demonstrated repeated exposures to Campylobacter throughout life, most of which do not lead to clinical symptoms. From young adulthood, >95% of the population in The Netherlands had serological evidence for exposure to Campylobacter.
据估计，荷兰每年由弯曲菌属引起的临床胃肠炎发作次数为 75000 次，即每 200 人生命年发生一次。这个数字是基于基于人群的研究中培养结果的推断得出的。弯曲菌感染的培养确诊病例数量在生命的头 3 年和 20 至 25 岁之间达到峰值。弯曲菌的血清流行病学描述了年龄与接触弯曲菌之间的关系，反映了有症状和无症状感染。使用经过验证的 ELISA 系统，在荷兰一般人群的 PIENTER 血清采集的年龄分层样本（n=456）中测量了针对弯曲菌的抗体。针对弯曲菌 IgG 抗体的血清阳性率随年龄增长而增加，在 20 岁时几乎达到 100%。抗体水平随年龄稳步增加，直到成年早期，表明反复接触弯曲菌。总之，血清流行病学数据表明一生中反复接触弯曲菌，其中大多数不会导致临床症状。从成年早期开始，荷兰超过 95%的人口有接触弯曲菌的血清学证据。
