慢性酒精摄入会降低外周淋巴结中 NK 细胞的百分比和数量，并加重 B16BL6 黑色素瘤向引流淋巴结的转移。
Chronic alcohol consumption decreases the percentage and number of NK cells in the peripheral lymph nodes and exacerbates B16BL6 melanoma metastasis into the draining lymph nodes.
机构信息
Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Pullman, WA 99164-6534, United States.
出版信息
Cell Immunol. 2011;266(2):172-9. doi: 10.1016/j.cellimm.2010.10.001. Epub 2010 Oct 25.
Abstract
NK cells in the lymph nodes play important roles in inhibiting tumor metastasis into draining lymph nodes. Previously, we reported that chronic alcohol consumption interferes with NK cell trafficking from the bone marrow to the spleen. Herein, we found that alcohol consumption decreases the numbers of NK cells in lymph nodes. Adoptive transfer experiments indicated that continued exposure of donor splenocytes to alcohol inhibits NK but not T cell trafficking to lymph nodes. Alcohol did not negatively affect CCR7(+) and CXCR3(+) NK cells, but decreased the percentage and number of CD62L(+) NK cells in the spleen, which are an important source of NK cell trafficking into the lymph nodes. These data suggest that modulation of the microenvironment associated with alcohol consumption impairs the trafficking of NK cells to lymph nodes. The decreased number of NK cells in the lymph nodes was associated with increased melanoma metastasis into the draining lymph nodes.
摘要
淋巴结中的 NK 细胞在抑制肿瘤转移到引流淋巴结中发挥重要作用。此前，我们报道过慢性酒精摄入会干扰 NK 细胞从骨髓向脾脏的迁移。在此，我们发现酒精摄入会减少淋巴结中的 NK 细胞数量。过继转移实验表明，供体脾细胞持续暴露于酒精中会抑制 NK 细胞而不是 T 细胞向淋巴结的迁移。酒精并没有对 CCR7(+)和 CXCR3(+)NK 细胞产生负面影响，而是减少了脾脏中 CD62L(+)NK 细胞的比例和数量，这是 NK 细胞向淋巴结迁移的重要来源。这些数据表明，与酒精摄入相关的微环境的调节会损害 NK 细胞向淋巴结的迁移。淋巴结中 NK 细胞数量的减少与黑色素瘤转移到引流淋巴结的增加有关。
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