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Hold me tight: Role of the heat shock protein family of chaperones in cardiac disease.抱紧我:伴侣蛋白热休克蛋白家族在心脏病中的作用。
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2
Role of the heat-shock response in the life and death of proteins.热休克反应在蛋白质的生死过程中的作用。
Ann N Y Acad Sci. 1998 Jun 30;851:99-111. doi: 10.1111/j.1749-6632.1998.tb08982.x.
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Feedback regulation of the heat shock response.热休克反应的反馈调节。
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Molecular chaperones and the heat shock response. Sponsored by Cold Spring Harbor Laboratory, 6-10 May 1998.分子伴侣与热休克反应。由冷泉港实验室主办,1998年5月6日至10日。
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[Stress response and molecular chaperones].[应激反应与分子伴侣]
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J Integr Bioinform. 2025 Jun 3;22(1). doi: 10.1515/jib-2024-0043. eCollection 2025 Mar 1.
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AI-Driven Prediction of Cardio-Oncology Biomarkers Through Protein Corona Analysis.通过蛋白质冠层分析实现人工智能驱动的心脏肿瘤生物标志物预测
Chem Eng J. 2025 Apr;509. doi: 10.1016/j.cej.2025.161134. Epub 2025 Mar 1.
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HSPD1 Supports Osteosarcoma Progression through Stabilizing ATP5A1 and thus Activation of AKT/mTOR Signaling.热休克蛋白 1 通过稳定 ATP5A1 从而激活 AKT/mTOR 信号通路促进骨肉瘤进展。
Int J Biol Sci. 2024 Sep 23;20(13):5162-5190. doi: 10.7150/ijbs.100015. eCollection 2024.
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Circular RNA-circPan3 attenuates cardiac hypertrophy via miR-320-3p/HSP20 axis.环状 RNA-circPan3 通过 miR-320-3p/HSP20 轴减轻心肌肥厚。
Cell Mol Biol Lett. 2024 Jan 3;29(1):3. doi: 10.1186/s11658-023-00520-2.
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The Role of Extracellular Heat Shock Proteins in Cardiovascular Diseases.细胞外热休克蛋白在心血管疾病中的作用
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Macrophage-Specific NLRC5 Protects From Cardiac Remodeling Through Interaction With HSPA8.巨噬细胞特异性NLRC5通过与HSPA8相互作用预防心脏重塑。
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Protein Quality Control at the Sarcomere: Titin Protection and Turnover and Implications for Disease Development.肌节中的蛋白质质量控制:肌联蛋白的保护、周转及其对疾病发展的影响
Front Physiol. 2022 Jun 30;13:914296. doi: 10.3389/fphys.2022.914296. eCollection 2022.
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Front Aging. 2022 Mar 3;3:844168. doi: 10.3389/fragi.2022.844168. eCollection 2022.
10
Analysis of Therapeutic Targets of A Novel Peptide Athycaltide-1 in the Treatment of Isoproterenol-Induced Pathological Myocardial Hypertrophy.新型肽 Athycaltide-1 治疗异丙肾上腺素诱导病理性心肌肥厚的治疗靶点分析。
Cardiovasc Ther. 2022 May 2;2022:2715084. doi: 10.1155/2022/2715084. eCollection 2022.

本文引用的文献

1
Mechanisms of the Hsp70 chaperone system.热休克蛋白 70 伴侣系统的作用机制。
Biochem Cell Biol. 2010 Apr;88(2):291-300. doi: 10.1139/o09-175.
2
Sent to destroy: the ubiquitin proteasome system regulates cell signaling and protein quality control in cardiovascular development and disease.摧毁目标:泛素蛋白酶体系统调节心血管发育和疾病中的细胞信号转导和蛋白质质量控制。
Circ Res. 2010 Feb 19;106(3):463-78. doi: 10.1161/CIRCRESAHA.109.208801.
3
Heat shock proteins: therapeutic drug targets for chronic neurodegeneration?热休克蛋白:慢性神经退行性变的治疗药物靶点?
Curr Pharm Biotechnol. 2010 Feb;11(2):198-215. doi: 10.2174/138920110790909641.
4
Regulation of heat shock protein 60 and 72 expression in the failing heart.热休克蛋白 60 和 72 在心力衰竭心脏中的表达调控。
J Mol Cell Cardiol. 2010 Feb;48(2):360-6. doi: 10.1016/j.yjmcc.2009.11.009. Epub 2009 Nov 27.
5
Modulation of Hsf1 activity by novobiocin and geldanamycin.新型霉素和格尔德霉素对 Hsf1 活性的调节。
Biochem Cell Biol. 2009 Dec;87(6):845-51. doi: 10.1139/o09-049.
6
Cardioprotection by CaMKII-deltaB is mediated by phosphorylation of heat shock factor 1 and subsequent expression of inducible heat shock protein 70.钙调蛋白依赖性蛋白激酶 II-δB 通过磷酸化热休克因子 1 和随后诱导性热休克蛋白 70 的表达实现心脏保护作用。
Circ Res. 2010 Jan 8;106(1):102-10. doi: 10.1161/CIRCRESAHA.109.210914. Epub 2009 Nov 12.
7
A novel mouse HSF3 has the potential to activate nonclassical heat-shock genes during heat shock.一种新型的小鼠 HSF3 在热休克时有可能激活非经典热休克基因。
Mol Biol Cell. 2010 Jan 1;21(1):106-16. doi: 10.1091/mbc.e09-07-0639. Epub 2009 Oct 28.
8
Blockade of Hsp20 phosphorylation exacerbates cardiac ischemia/reperfusion injury by suppressed autophagy and increased cell death.热休克蛋白20(Hsp20)磷酸化的阻断通过抑制自噬和增加细胞死亡加重心脏缺血/再灌注损伤。
Circ Res. 2009 Dec 4;105(12):1223-31. doi: 10.1161/CIRCRESAHA.109.200378. Epub 2009 Oct 22.
9
Integrating the cell stress response: a new view of molecular chaperones as immunological and physiological homeostatic regulators.整合细胞应激反应:分子伴侣作为免疫和生理动态平衡调节剂的新视角。
Cell Biochem Funct. 2010 Jan;28(1):1-14. doi: 10.1002/cbf.1609.
10
Heat-shock protein 60 and cardiovascular disease: a paradoxical role.热休克蛋白60与心血管疾病:一个矛盾的角色。
Future Cardiol. 2008 Mar;4(2):151-61. doi: 10.2217/14796678.4.2.151.

Hold me tight: Role of the heat shock protein family of chaperones in cardiac disease.

作者信息

Willis Monte S, Patterson Cam

机构信息

McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7126, USA.

出版信息

Circulation. 2010 Oct 26;122(17):1740-51. doi: 10.1161/CIRCULATIONAHA.110.942250.

DOI:10.1161/CIRCULATIONAHA.110.942250
PMID:20975010
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2976481/
Abstract
摘要