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上皮-间质转化与衰老：两个与癌症相关的过程正相互交织。

Epithelial-mesenchymal transition and senescence: two cancer-related processes are crossing paths.

作者信息

Smit Marjon A, Peeper Daniel S

机构信息

The Netherlands Cancer Institute, Amsterdam, The Netherlands.

出版信息

Aging (Albany NY). 2010 Oct;2(10):735-41. doi: 10.18632/aging.100209.

DOI:10.18632/aging.100209
PMID:20975209
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2993803/
Abstract

The epithelial-mesenchymal transition is involved in several physiological processes. However, it is also believed to contribute to cancer progression. Conversely, cellular senescence constitutes a failsafe program against cancer progression. Interestingly, EMT and senescence seem to cross paths, with several factors playing dominant roles in both settings. Here, we describe recent observations that link these important cellular processes.

摘要

上皮-间质转化参与多种生理过程。然而，人们也认为它会促进癌症进展。相反，细胞衰老构成了一种对抗癌症进展的安全机制。有趣的是，上皮-间质转化和衰老似乎相互关联，有几个因素在这两种情况下都起着主导作用。在此，我们描述了将这些重要细胞过程联系起来的最新观察结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f50/2993803/61e022529a1d/aging-02-735-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f50/2993803/61e022529a1d/aging-02-735-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f50/2993803/61e022529a1d/aging-02-735-g001.jpg

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