Spanish National Cancer Research Centre, Madrid, Spain.
Nat Rev Cancer. 2010 Jan;10(1):51-7. doi: 10.1038/nrc2772.
The importance of cellular senescence, which is a stress response that stably blocks proliferation, is increasingly being recognized. Senescence is prevalent in pre-malignant tumours, and progression to malignancy requires evading senescence. Malignant tumours, however, may still undergo senescence owing to interventions that restore tumour suppressor function or inactivate oncogenes. Senescent tumour cells can be cleared by immune cells, which may result in efficient tumour regression. Standard chemotherapy also has the potential to induce senescence, which may partly underlie its therapeutic activity. Although these concepts are well supported in mouse models, translating them to clinical oncology remains a challenge.
细胞衰老作为一种稳定阻止增殖的应激反应，其重要性正日益受到重视。衰老普遍存在于恶性前期肿瘤中，而向恶性肿瘤的进展则需要逃避衰老。然而，由于恢复肿瘤抑制功能或失活癌基因的干预，恶性肿瘤仍可能发生衰老。衰老的肿瘤细胞可以被免疫细胞清除，这可能导致肿瘤的有效消退。标准的化疗也有可能诱导衰老，这可能是其治疗活性的部分基础。尽管这些概念在小鼠模型中得到了很好的支持，但将其转化为临床肿瘤学仍然是一个挑战。
