GE Global Research, Chemical Technology and Materials Characterization Laboratory, Niskayuna, NY 12309, USA.
Chem Commun (Camb). 2010 Dec 21;46(47):8956-8. doi: 10.1039/c0cc03302b. Epub 2010 Oct 25.
Water-soluble ≤6 nm tantalum oxide nanoparticles have been synthesized and characterized in solution using HPLC-ICP, DLS, and multinuclear NMR. Nanoparticle formulation permitted intravenous injection, in vivo imaging, and subsequent renal clearance. A clinical CT scanner provided excellent resolution following agent injection, and distribution to the arterial system was visualized. In vitro CT imaging studies indicated that at equal molar concentration of tantalum and iodine, tantalum produced greater image contrast than iodine across the diagnostic X-ray spectrum with contrast benefit increasing with peak X-ray energy.
已在溶液中通过 HPLC-ICP、DLS 和多核 NMR 合成并表征了水溶性≤6nm 的氧化钽纳米粒子。纳米粒子配方允许进行静脉注射、体内成像和随后的肾脏清除。临床 CT 扫描仪在注入造影剂后提供了出色的分辨率，并可观察到造影剂在动脉系统中的分布。体外 CT 成像研究表明，在钽和碘的等摩尔浓度下，钽在整个诊断 X 射线光谱范围内产生的图像对比度大于碘，且对比度随峰值 X 射线能量的增加而增加。
